NRP1 as multifunctional non-tyrosine-kinase receptors play critical roles in tumor progression. MicroRNAs (miRNAs) are an important class of pervasive genes that are involved in a variety of biological functions, particularly cancer. It remains unclear whether miRNAs can regulate the expression of NRP1. The goal of this study was to identify miRNAs that could inhibit the growth, invasion and me...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 205 4.6 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 276 6.2 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 367 8.2 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 312 7.0 20 to 24 years . . . . . . . . . . . . . . . . . . . . ....

Hypoxia is a common feature of solid tumors and an important contributor to anti-tumor drug resistance. Hypoxia inducible factor-1 (HIF-1) is one of the key mediators of the hypoxia signaling pathway, and was recently proven to be required for sorafenib resistance in hepatocarcinoma (HCC). MicroRNAs have emerged as important posttranslational regulators in HCC. It was reported that miR-338-3p l...

BACKGROUND The current study aims to elucidate the role of miRNA-338-3p (miR-338-3p) in the invasion of renal cell carcinoma (RCC). METHODS Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to detect the expression of miR-338-3p in human RCC cell lines with high metastatic potential (Caki-1) and low metastatic potential (786-O), respectively. The Caki-1 and ...

microRNA-338-3p (miR-338-3p) has been implicated in tumor development and progression in many types of cancers. However, the function and mechanism underlying the action of miR-383-3p in thyroid cancer remain unclear and were therefore investigated in this study by in vitro and in vivo experiments. We found that miR-338-3p was downregulated in thyroid cancer tissues and cell lines. miR-338-3p e...

three-dimensional objects. Douglas and colleagues’ work represents a third revolution in DNA nanotechnology. They have extended the DNA origami technique by showing how a DNA scaffold strand can form layers of helices arranged in a honeycomb lattice, thus providing a general-purpose, crystalline material from which three-dimensional objects can be constructed. In principle, any shape can be mad...

OBJECTIVES We administered aerosolized histamine to 32 subjects with tetraplegia to determine whether there were differences in spirometric and/or lung volume parameters between responders and nonresponders. RESULTS Baseline pulmonary function parameters revealed mild to moderate restrictive dysfunction. We found that 25 subjects (78%) were hyperreactive to histamine (mean provocative concent...

about 38% for females and 28% for males. In an ongoing study, mice are being fed rapamycin beginning at 270 days, with a significant increase in survival also being apparent in this cohort. Rapamycin was first identified as a natural product of the bacterium Streptomyces hygroscopicus in soil samples from Easter Island — famous for its impressive rock-carved human statues (Fig. 1). The compound...