The aim of this review is to show how Electron Paramagnetic Resonance (EPR) and related methods such as dynamic nuclear polarisation (DNP) can be used to detect, localize and quantify oxygen concentration in biological tissues. Several applications will be described with special emphasis on tumor oxygenation. Introduction It is well established that the partial pressure of oxygen (pO2) plays im...

Initial information on the newly discovered hormone leptin suggests a primary role in energy balance and body weight maintenance. Recent published information suggests that leptin has an impact on several physiological systems, including neuroendocrine and immune function, as well as being involved in growth and development. Although the role of leptin in these areas is only partially understoo...

Perhaps one of the most devastating diabetes complications is diabetic embryopathy, in which the offspring of a mother with diabetes predating pregnancy develops congenital malformations. These malformations can affect multiple organ systems, including the brain and spinal cord, the heart and major vessel, the kidneys, the gut, and skeletal structures (1,2) and result in preor postnatal mortali...

Apicella, Paul, Sabrina Ravel, Pierangelo Sardo, and Eric Leend, we compared the activity of tonic striatal neurons during gallet. Influence of predictive information on responses of tonically performance of a simple reaction time task in the presence active neurons in the monkey striatum. J. Neurophysiol. 80: 3341– and absence of an instruction cue presented at a fixed interval 3344, 1998. We ...

Experimental induction of a polycystic ovarian syndrome (PCOS) in rodents by the administration of a single dose of estradiol valerate (EV) results in activation of the peripheral sympathetic neurons that innervate the ovary. This activation is evidenced by an increased capacity of ovarian nerve terminals to incorporate and release norepinephrine (NE), an increase in ovarian NE content, and a d...

Pharmacogenomics is poised to radically alter the way drugs are designed, developed, and prescribed. Given that much of the variation in drug response can be attributed to genetic differences, tailoring drugs to an individual’s unique genetic signature provides the opportunity to reduce adverse drug events, improve drug efficacy, optimize trial design, and prevent costly drug recalls (1 ). Deve...

BACKGROUND Stroke is the major cause of adult disability. Selective serotonin reuptake inhibitors (SSRIs) have been used for many years to manage depression. Recently, small trials have demonstrated that SSRIs might improve recovery after stroke, even in people who are not depressed. Systematic reviews and meta-analyses are the least biased way to bring together data from several trials. Given ...

Initial information on the newly discovered hormone leptin suggests a primary role in energy balance and body weight maintenance. Recent published information suggests that leptin has an impact on several physiological systems, including neuroendocrine and immune function, as well as being involved in growth and development. Although the role of leptin in these areas is only partially understoo...

No AccessEngineering NotesIndirect Optimization of Power-Limited Asteroid Rendezvous TrajectoriesYang Wang and Francesco TopputoYang WangPolytechnic University Milan, 20156 Italy*Ph.D. Candidate, Department Aerospace Science Technology, Via La Masa 34; (Corresponding Author).Search for more papers by this author Topputo https://orcid.org/0000-0002-5369-6887Polytechnic Italy†Full Professor, . Se...

Purpose: Is retention of γH2AX foci useful as a biomarker for predicting the response of xenograft tumors to cisplatin with X-ray? Is a similar approach feasible using biopsies from patients with cervical cancer? Experimental Design: Mice bearing SiHa, WiDr, or HCT116 xenograft tumors were exposed to cisplatin and/or three daily doses of 2 Gy. Tumors were excised 24 h after treatment and single...