Fast-twitch skeletal muscles are specialized for in vivo motor functions that require high power (mastication and load lifting), high speed (eyelid blink), or a combination of the two (withdrawal reflexes and escape responses). Those functions that rely on high power often involve tetanic stimulation of the effector muscles, resulting in sustained force generation even during tetani that are no...

Most studies have looked at the distribution of well-being or its change over time in terms of income. However, family wealth is also an indicator of well-being, independent of the direct financial income it provides. There are four reasons. First, owner-occupied housing provides services directly to their owner. Second, wealth is a source of consumption, independent of the direct money income ...

Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing tha...

Fast-twitch skeletal muscles are specialized for in vivo motor functions that require high power (mastication and load lifting), high speed (eyelid blink), or a combination of the two (withdrawal reflexes and escape responses). Those functions that rely on high power often involve tetanic stimulation of the effector muscles, resulting in sustained force generation even during tetani that are no...

The migration patterns of naive and activated T cells are associated with the expression of distinct sets of chemokine receptors, but the molecular basis for this regulation is unknown. Here we identify Krupple-like factor 2 (KLF2) as a key transcriptional factor needed to prevent naive T cells from expressing inflammatory chemokine receptors and acquiring the migration patterns of activated T ...