Oxidative stress and excitotoxicity have been implicated in selective striatal vulnerability caused by the mitochondrial toxin, 3-nitropropionic acid (3-NP), which may simulate Huntington's disease in animals and humans. The detailed mechanism of the role of superoxide in striatal vulnerability induced by 3-NP is still unknown. The authors investigated oxidative cellular injury and DNA fragment...

Purpose: Because the nongenotoxic inhibitor of the p53/MDM2 interactions Nutlin-3 has shown promising in vitro therapeutic activity against a variety of p53 cancer cells, in this study we evaluated an innovative strategy able to specifically target Nutlin-3 toward CD20þ malignant cells. Experimental Design: The cytotoxic effects of Nutlin-3 encapsulated into poly(lactide-co-glycolide) nanoparti...

We analyze the data distributions f(h), f(Nc) and f(Np) of Hirsch index (h), total citations (Nc) number papers (Np) top scoring 120,000 authors (scientists) from Stanford cite-score (or c-score) 2022 list their corresponding h (3≤h≤284), Nc(1009≤Nc≤428620) Np (3≤Np≤3791) statistics Scopus data. For reasons explained in text, we divided these scorers (c-scores range 5.6125 to 3.3461) into six s...

Nonylphenol (NP) has been widely used for more than 50 years in the synthesis of NP ethoxylates, which are important nonionic surfactants. NP is considered an endocrine disruptor based on in vitro and in vivo animal studies. However, the toxic effects of NP in humans are unknown. Information regarding the metabolic fate of 4-t-nonylphenol (4-tNP), a mixture of commercial NP branched isomers, in...

A graph [Formula: see text] is well-covered if all its maximal independent sets are of the same cardinality. Assume that a weight function defined on vertices. Then text]well-covered weight. For every text], set functions such text]-well-covered vector space, denoted as WCW(G). Deciding whether an input co-NP-complete. Therefore, finding WCW(G) co-NP-hard. generating subgraph induced complete b...

Considering the contention for communication resources in task scheduling is discussed in [3]. Theorem 1 of [3] states the NP-completeness of the associated decision problem and the corresponding proof shows NP-completeness in the weak sense [2]. Here, a new proof is presented for Theorem 1 of [3] that shows NP-completeness in the strong sense. The proof is based on a reduction from the well-kn...

Huntington’s disease is an autosomal-dominant, progressive neurodegenerative disorder with chorea, incoordination, cognitive decline, and behavioral difficulties, whereas bioflavonoids have the potential to promote anxiety depression. The aim of this study was investigate summarize synergistic effect silymarin, quercetin, hesperidin on depression in 3-nitropropionic acid (3-NP)-induced rat mode...

Nanostructured β-CoMoO₄ catalysts have been prepared via the thermal decomposition of an oxalate precursor. The catalyst was characterized by infrared spectroscopy (FTIR), X-ray diffraction (XRD), Brunauer-Emmett-Teller method (BET), energy dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM). The efficiency of these nanoparticles in the reduction of ortho- and meta-n...

An impairment of energy metabolism may underlie slow excitotoxic neuronal death in neurodegenerative diseases. We therefore examined the effects of intrastriatal, subacute systemic, or chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid (3-NP) in rats. Following intrastriatal injection 3-NP produced dose-dependent striatal lesions. Neurochemical and histologic evalu...