I b a t fi ACKGROUND ome cases of unexplained recurrent spontaneous pregnancy oss have been proposed to arise from an undefined immuological barrier to normal placentation. One proposed treatent, active immunization with allogeneic leukocytes, benfits only 8% to 10% of treated couples, who cannot be elected by means of diagnostic testing (1). Another treatent, passive immunization with intraven...

In a subgroup of patients suffering from atopic dermatitis (AD), treatment is quite difficult even after taking oral immunosuppressants. High-dose intravenous immunoglobulin (IVIG) treatment has been reported to be beneficial for them in a few uncontrolled trials. Herein we report a case of intractable AD in a 5-year-old girl who had significant clinical improvement after receiving 3 cycles of ...

Pemphigus vulgaris (PV) is a potentially lethal mucocutaneous blistering disease characterized by cell-cell detachment within the stratified epithelium (acantholysis) caused by IgG autoantibodies. Intravenous immunoglobulin (IVIg) therapy effectively treats PV, but the mechanism is not fully understood. To further understand acantholysis and the efficacy of IVIg, we measured effects of IgG frac...

Kawasaki disease (KD) is the most common cause of acquired heart disease in children in developed countries.(1,2) The primary goal of treatment is to prevent coronary artery aneurysms (CAA). Between 10 and 20% of KD patients are resistant to treatment with intravenous immunoglobulin (IVIG) and have an almost nine-fold increased risk of developing CAA.(3) In addition, approximately 80-90% of pat...

Sir, I read with interest the case report by James et al. on the cerebral venous thrombosis after intravenous immunoglobulin (IVIG) therapy in a patient with immune thrombocytopenic purpura.[1] The case report generally supports the trend of increasing reports of IVIG‐associated thrombotic events in all age groups, including pediatric age group.[2] It is obvious that the tolerance of IG is usua...

BACKGROUND Myocarditis frequently occurs in the acute phase of Kawasaki syndrome (KS), and a few severe cases have been reported. Four cases of myocarditis in KS required additional catecholamine treatment because of severe left ventricular dysfunction (LVD). CASE REPORTS Three cases were relatively older children and 2 cases were complicated with encephalopathy. All 4 developed coronary arte...

Methods The changes in sepsis markers (procalcitonin, presepsin, interleukin-6, Creactive protein) followed by IVIg administration were investigated in severe sepsis or septic shock patients. The subjects were 410 patients admitted to an ICU with a diagnosis of severe sepsis or septic shock and from whom informed consent had been obtained for the present study. IVIg was administered intravenous...

objective guillain-barre syndrome (gbs) is the most common cause of acute neuromuscular paralysis in children, its pathogenesis most probably involving an autoimmune response to schwann cell or peripheral nerve myelin antigens. steroid regimes improve demyelinating diseases such as chronic gbs. we assessed the benefit of high dose methylprednisolone (mp) combined with intravenous immunoglobulin...

Intravenous immunoglobulin G (IVIg) is widely used against a range of clinical symptoms. For its use in immune modulating therapies such as treatment of immune thrombocytopenic purpura high doses of IVIg are required. It has been suggested that only a fraction of IVIg causes this anti immune modulating effect. Recent studies indicated that this fraction is the Fc-sialylated IgG fraction. The ai...

Transient hypogammaglobulinemia of infancy (THI) is characterized by recurrent infections and one or more reduced serum immunoglobulin levels. Typically, THI patients recover spontaneously, mostly within 30-40 months of age, but sometimes recovery may be delayed until 5-6 years of age. The use of intravenous immunoglobulin (IVIg) as an alternative to antibiotic prophylaxis remains contraversial...