The third extracellular loop of the human delta-opioid receptor (hDOR) is known to play an important role in the binding of delta-selective ligands. In particular, mutation of three amino acids (Trp(284), Val(296), and Val(297)) to alanine significantly diminished delta-opioid receptor affinity for delta-selective ligands. To assess the changes in conformation accompanying binding of the endoge...

299 Community Policing in America: Changing the Nature, Structure, and Function of the Police

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[This corrects the article DOI: 10.18632/oncoscience.299.].

Case name: Doe v. Haverford College, No. 23‐299 (E.D. Pa. 02/14/23).

Single-unit recording studies were undertaken in chloral hydrate-anesthetized rats to compare the effects on dorsal raphe cell firing of several putative 5-hydroxytryptamine (HT)1A receptor antagonists, including WAY 100635 (N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide), p-MPPI (4-(2-methoxyphenyl)1-[2'-[N-(2"-pyridinyl)-p-iodobenzamido]ethyl] pip erazin...

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the expression of protein-coding genes by partially binding to specific target sites of mRNAs. miRNAs perform important functions in complicated cellular biological processes and their abnormal expression is involved in various disorders, including cancer. Among the miRNAs, differential expression of miR-139-5p serves a significant role...

Fingerprinting schemes deter people from illegally redistributing digital data by enabling the original merchant of the data to identify the original buyer of a redistributed copy. So-called traitor-tracing schemes have the same goal for keys used to decrypt information that is broadcast in encrypted form. Recently, asymmetric fingerprinting and traitor-tracing schemes were introduced. Here, on...

An accurate retrieval system is essential to the performance of any case-based reasoning (CBR) system. This paper describes a new retrieval method in which both feature similarity and adaptation knowledge are used to guide retrieval. A system can only improve its performance by learning and CBR systems learn mainly by storing newly adapted cases. The system has better opportunities to learn use...