Background: Investigating predictors of response to antiHCV therapy may avoid the current expensive therapy associated with various side effects. Aim of Work: To test for the hypothesis claiming that single nucleotide polymorphism (SNP) in the IL-28B gene might affect the response to antiviral treatment. The SNP rs12979860 C>T in the IL-28B gene was assayed, and its influence on response to HCV...

background treatment with peginterferon alpha-2b plus ribavirin is the current standard therapy for chronic hepatitis c (chc). however, many host related and viral parameters are associated with different outcomes of combination therapy. objectives the aim of this study was to develop an artificial neural network (ann) model to predetermine individual responses to therapy based on patient’s dem...

INTRODUCTION Single-nucleotide polymorphisms (SNPs) in the region of the Interleukin 28B (IL28B) gene on chromosome 19, coding for the interferon (IFN)-λ3, are involved in hepatitis c virus (HCV), spontaneous clearance. There is little information on the degree of liver fibrosis (LF) in HIV patients, who have had spontaneous clearance of HCV. Our objective in this study is to assess the degree ...

BACKGROUND Treatment with Peginterferon Alpha-2b plus Ribavirin is the current standard therapy for chronic hepatitis C (CHC). However, many host related and viral parameters are associated with different outcomes of combination therapy. OBJECTIVES The aim of this study was to develop an artificial neural network (ANN) model to predetermine individual responses to therapy based on patient's d...

There are accurate but inconclusive data on the association between single nucleotide polymorphisms (SNPs) of interleukin (IL)-28B and sustained virological response (SVR) in chronic hepatitis C (CHC). This meta-analysis aimed to derive a more precise estimation of the effects of IL-28B SNPs locus (rs12979860 and rs8099917) on SVR in naïve CHC patients receiving pegylated interferon alpha (PEG-...

BACKGROUND AND AIMS Genetic polymorphisms near interleukin 28B gene are associated with spontaneous and treatment induced clearance of hepatitis C virus (HCV). Our objective was to evaluate the impact of interleukin 28B single nucleotide polymorphism (rs12979860, rs8099917) variability in HCV genotype 3 infected populations. METHODS 400 hepatitis C seroreactive patients from different populat...

BACKGROUND/AIMS The impact of virological factors and interleukin-28B (IL-28B) genetic variants on retreatment of hepatitis C virus genotype 2 (HCV-2) treatment-experienced patients remains unknown. METHODS On-treatment virological responses and IL-28B rs8099917 genotype were determined in 46 HCV-2 treatment-experienced patients (42 previous relapsers; four previous non-responders) retreated ...

A rapid, duplex, high-resolution melting interleukin-28B gene (IL28B) genotyping assay, targeting both rs12979860 and rs8099917 polymorphisms, was developed and validated using 30 DNA samples from healthy volunteers. A linkage study on 300 healthy Singaporeans showed variable haplotypes. When the assay was applied to plasma DNA from 50 hepatitis C virus genotype-1 (HCV-1)-infected patients, fiv...