PURPOSE The aim of this study was to confirm the prognostic significance of POLE exonuclease domain mutations (EDM) in endometrial carcinoma patients. In addition, the effect of treatment on POLE-mutated tumors was assessed. EXPERIMENTAL DESIGN A retrospective patient cohort of 496 endometrial carcinoma patients was identified for targeted sequencing of the POLE exonuclease domain, yielding 4...

Massive halos of hot plasma exist around some, but not all elliptical galaxies. There is evidence that this is related to the age of the galaxy. In this paper new X-ray observations are presented for three early-type galaxies that show evidence of youth, in order to investigate their X-ray components and properties. NGC 5363 and NGC 2865 were found to have X-ray emission dominated by purely dis...

Abstract Background Transcatheter edge-to-edge repair (TEER) with the MitraClip system is an alternative procedure for treatment of severe mitral regurgitation (MR) in high-risk patients who are not suitable conventional surgery and usually performed under general anaesthesia (GA). GA may be associated potential haemodynamic complications. A new approach deep sedation (DS) spontaneous breathing...

Skeletal muscle and myocardium express microNOS I, an elongated splice variant of neuronal-type nitric oxide (NO) synthase (NOS I), and NOS III, endothelial-type NO synthase, respectively. This study was designed to elucidate whether vascular smooth muscle also contains a constitutively expressed NO synthase isoform. In the rat, microNOS I contains an insert of 102 nucleotides after nucleotide ...

BACKGROUND This study was designed to determine whether an automated hospital-based influenza vaccination screening program leveraging the electronic medical record (EMR) increases vaccination rates. METHODS We performed a retrospective cohort study of all children ≥6 months old admitted to medical, surgical, rehabilitation, or psychiatry services during influenza seasons between 2003 and 201...

BACKGROUND Vaginal infections are a risk factor for preterm delivery. In this study, we sought to evaluate the vaginal flora of pregnant women receiving opioid maintenance therapy (OMT) in comparison to non-dependent, non-maintained controls. METHODS A total of 3763 women with singleton pregnancies who underwent routine screening for asymptomatic vaginal infections between 10 + 0 and 16 + 0 g...

Adolescents' exposure to a peer's suicide has been found to be associated with, as well as to predict, suicidal ideation and behavior. Although postvention efforts tend to be school-based, little is known about the impact of a schoolmate's suicide on the school's student population overall. The present study seeks to determine whether there is excess psychological morbidity among students in a ...

BACKGROUND Consumption of caffeinated beverages such as coffee and tea has been associated with a lower risk of type 2 diabetes (T2D). Paradoxically, short-term metabolic studies have shown that caffeine impairs postprandial glycemic control. OBJECTIVE The objective was to prospectively examine the association of caffeinated compared with caffeine-free beverages, including coffee, tea, sugar-...