نتایج جستجو برای: 2762
تعداد نتایج: 113 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE Stroke mortality rates and case fatality of stroke have declined since the beginning of the 1970s in Sweden, but the incidence of stroke has been stable. The aim of this study was to analyze trends in long-term survival after stroke. METHODS Within the framework of the population-based WHO Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MO...
Background—The relation between serum lipids and risk of coronary events has been established, but there are no data demonstrating directly the relation between serum low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol versus serial changes in coronary plaque dimensions. Methods and Results—We performed standard analyses of serial intravascular ultrasound (I...
BACKGROUND Psychostimulants and non stimulants are effective in the treatment of ADHD. Efficacy of both methylphenidate and atomoxetine has been established in placebo controlled trials. Direct comparison of efficacy is now possible due to availability of results from several head-to-head trials of these two medications. METHODS All published, randomized, open label or double blind trials, co...
OBJECTIVE To explore the relationship between hepatitis C virus (HCV)/HIV coinfection and responses to initial antiretroviral treatment (ART). METHODS Four AIDS Clinical Trials Group HIV treatment studies' data were combined to compare initial ART responses between HCV/HIV-coinfected and HIV-monoinfected patients as evaluated by virologic failure, CD4 cell measures, occurrence of AIDS/death a...
Background: Hitherto metastatic colorectal cancer (mCRC) is the basis for second-leading death of all cancers. As first-line chemotherapy in mCRC treatment, an antiangiogenic combination bevacizumab with FOLFOX4 improved competence and overall survival (OS). We developed a new hybrid small molecule dual properties as therapy to study its synergistic effect on CRC cell lines patient-derived orga...
The cytochrome P450, CYP2C8, metabolizes more than 60 clinically used drugs as well as endogenous substances including retinoic acid and arachidonic acid. However, predictive factors for interindividual variability in the efficacy and toxicity of CYP2C8 drug substrates are essentially lacking. Recently we demonstrated that peroxisome proliferator-activated receptor alpha (PPARα), a nuclear rece...
OBJECTIVE To explore the occurrence and characteristics of aggressive multiple sclerosis (AMS) in adult-onset multiple sclerosis (MS) patients. METHODS Prospectively collected data (1980-2009) from British Columbia, Canada, were retrospectively analysed. AMS was defined in three different ways (AMS1, 2 and 3): 'AMS1'--confirmed Expanded Disability Status Scale (EDSS) ≥ 6 within 5 years of MS ...
AIMS The globalization of clinical trials has highlighted geographic variations in patient characteristics, event rates, and treatment effects. We investigated these further in PARADIGM-HF, the largest and most globally representative trial in heart failure (HF) to date. METHODS AND RESULTS We looked at five regions: North America (NA) 602 (8%), Western Europe (WE) 1680 (20%), Central/Eastern...
هدف از این تحقیق بررسی ویژگی‌های مکانیکی تخته فیبر دانسیته متوسط تولید داخلی و تخته فیبر دانسیته متوسط وارداتی (کشور مالزی) بوده است. به دلیل عدم شناخت و عدم دسترسی به اطلاعات عوامل و متغیرهای تأثیرگذار متعدد در تولید اوراق تخته فیبر در صنعت به‌ویژه تخته‌های وارداتی، برای درک بهتر تفاوت‌ها از اشعه مادون‌قرمز برای نمایان کردن پروفیل دانسیته عمودی تخته‌ها و طیف سنجی مادون‌قرمز (FT_IR)، جهت شناسا...
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