Mitotic-linked death is generally regarded as the mode of radiation-induced cell death, particularly in late-responding normal tissues, such as those found in the central nervous system. We have recently reported evidence for radiation-induced apoptosis in the central nervous system using the adult rat spinal cord model. Glial cells, but not neurons or vascular endothelial cells, appeared to un...

PURPOSE Predicting late effects in patients treated with radiation therapy by assessing in vitro radiation-induced CD4 and CD8 T-lymphocyte apoptosis can be useful in individualizing treatment. EXPERIMENTAL DESIGN In a prospective study, 399 curatively irradiated patients were tested using a rapid assay where fresh blood samples were in vitro irradiated with 8 Gy X-rays. Lymphocytes were coll...

We evaluated the chromosomal aberration (CA) frequencies in the peripheral blood lymphocytes of ten female patients, age average 43.7 +/- 12.9, with thyroid cancer (TC) who had been exposed to 100-200 mCi therapeutic doses of 131I. The blood samples were obtained before-treatment and at 2 and 24 h after-treatment. Radiation was measured in the samples by means of dysprosium-activated calcium su...

OBJECTIVES/HYPOTHESIS Postoperative radiation therapy is often used in patients with high-risk salivary gland carcinomas. In this study we evaluated the outcomes and prognostic factors in patients with minor salivary gland cancers treated with adjuvant radiation therapy. STUDY DESIGN Retrospective cohort study. METHODS We performed a retrospective analysis of 90 patients treated with curati...

BACKGROUND Preclinical studies suggest a synergistic effect between radiation, immunotherapy and anti-angiogenic therapy, although the mechanisms are unclear. Angiogenic cytokines are known to affect the immune system, and their levels may be associated with response to immunotherapy. Here, we assess changes in circulating VEGF, as well as angiogenic cytokines angiopoietin-1 and -2 (Ang1, Ang2)...

background:  radiochromic film is used for radiation dose measurement, xr-rv3 is used in fluoroscopy and ebt2 film in radiation therapy. the aim was to determine if the dosimetric properties of these two films are comparable in megavolt photon beams. materials and methods: comparison measurements included: calibration curves, heterogeneous phantom dose profiles, and nasopharynx dose distributio...