This second Theme Issue of ‘The virtual physiological human: computer simulation for integrative biomedicine’ continues to explore in detail the potential of the virtual physiological human (VPH) approach (Fenner et al. 2008). The initial editorial communication on the VPH training challenges (Lawford et al. 2010) illustrates some of the tasks and solutions for an integrated (across Europe) app...

Health reforms that emphasize public health and improvements in primary care can be cost-effective measures to achieve health improvements, especially in developing countries that face severe resource constraints. In their paper “Shanghai rising: health improvements as measured by avoidable mortality since 2000,” Gusmano et al suggest that Shanghai’s health policy-makers have been successful in...

Upper tract urothelial carcinoma (UTUC) is rare and occupied 5% of the urothelial carcinoma (Munoz and Ellison, 2000; Siegel et al., 2013). The standard treatment of UTUC is nephroureterectomy (NU) with bladder cuff resection which means one kidney would be lost after this extirpative management. It yields high risk of followed chronic kidney disease and makes following pharmacotherapy treatmen...

Recent efforts to include mobile and other non-standard ground-based radar data in ensemble analyses of severe convective storms have yielded promising results (e.g., Marquis et al. 2010; Snook et al. 2011; Tanamachi et al. 2012). During Project VORTEX2 (Wurman et al. 2010), the field phase of which occurred in spring 2009 and spring 2010, coordinated mobile Doppler radar deployments resulted i...

More than 100 years ago Abraham Flexner’s report changed medical education in the United States (USA) and consequently worldwide. He simply used a gold standard against which all medical schools at that time were measured (Cook et al., 2010). The report at that time was concerned mainly with undergraduate medical education. Since then medical education has developed immensely and flourished int...

Research on acquisition has established a clear asymmetry between subject (1) and object (2) A’-dependencies, with the former being mastered earlier than the latter (Avrutin, 2000, de Villiers, de Villiers, Hoban, 1994, Goodluck & Tavakolian, 1982, for English; Corrêa, 1995, Costa et. al, 2011, for Portuguese; Arnon, 2005, 2010, Friedmann & Novogrodsky, 2004, for Hebrew; Adani et al., 2010, Ada...

Supracondylar fractures of the femur after total knee arthroplasty are an uncommon but highly challenging injury (Streubel et al., 2010). The management of distal femoral fractures following a total knee replacement can be complex and requires the equipment, perioperative support and surgical skills of both trauma and revision arthroplasty services (Johnston et al., 2011, Nauth et al., 2011). T...

health reforms that emphasize public health and improvements in primary care can be cost-effective measures to achieve health improvements, especially in developing countries that face severe resource constraints. in their paper “shanghai rising: health improvements as measured by avoidable mortality since 2000,” gusmano et al suggest that shanghai’s health policy-makers have been successful in...

Correspondence: [email protected] School of Mathematical Science, Anhui University, Hefei 230039, PR China Abstract Some probability inequalities for extended negatively dependent (END) sequence are provided. Using the probability inequalities, we present some moment inequalities, especially the Rosenthal-type inequality for END sequence. At last, we study the asymptotic approximation of inverse m...

In the mammalian brain, neurogenesis constitutively occurs in the subventricular zone (SVZ), the olfactory bulb, and the hippocampus throughout adulthood (Kuhn et al., 1996; Lois and Alvarez-Buylla, 1993; Gage, 2000; Pagano et al., 2000; Gritti et al., 2002), and adult hippocampal neurogenesis plays an important role in learning and memory (Deng et al., 2010). In the hippocampus, multipotent ne...