BACKGROUND ODM-201 is a novel second-generation androgen receptor inhibitor for the treatment of metastatic castration-resistant prostate cancer (mCRPC). OBJECTIVE To evaluate the pharmacokinetics of ODM-201 tablet products and preliminary long-term safety, tolerability, and antitumor activity of ODM-201 in chemotherapy-naive men with mCRPC. DESIGN, SETTING, AND PARTICIPANTS Thirty patients...

Following intravenous administration, the myocardial concentration of tracer thallium-201, potassium-43, and rubidium-81 were determined in mice; thallium was present in the greatest concentration in the myocardium (2.08% compared 1.25% for potassium and 1.15% for rubidium at 10 minutes). The regional myocardial distribution of thallium-201 was determined in dogs under conditions of normal flow...

The sensitivity of myocardial perfusion imaging (MPI) using thallium-201 injected both at rest and during peak exercise was compared to simultaneously recorded 12 lead electrocardiography (ECG) for the detection of transient ischemia in 20 normal subjects and 63 patients with coronary artery disease (CAD). No significant perfusion defects or ECG changes were seen on either the rest or exercise ...

Correspondence to: Dr Y H Chan Tel: (65) 6325 7070 Fax: (65) 6324 2700 Email: chanyh@ cteru.com.sg In the 100 series(1-4) the common univariate techniques (summarized in Table I) available for data analyses were discussed. These techniques do not allow us to take into account the effect of other covariates/ confounders (except for partial correlation(4)) in an analysis. In such situations, a Re...

Following intranasal administration of radioactive (86)Rb(+) and (201)Tl(+) in mice, we observed this direct transport via the olfactory nerve pathway. The (86)RbCl and (201)TlCl solutions were administered to two groups of mice, the unilateral intranasal and intravenous administration groups. After sacrifice, their heads were divided into the right and left side, which were then subdivided int...

We report here identification of novel mimicry epitopes for interphotoreceptor retinoid-binding protein (IRBP) 201-216, a candidate ocular antigen that causes experimental autoimmune uveoretinitis (EAU) in A/J mice. One mimicry epitope from Ehrlichia canis (EHC), designated EHC 44-59, induced cross-reactive T cells for IRBP 201-216 capable of producing T helper (Th)1 and Th17 cytokines, but fai...

T he use of vasodilator thallium-201 myocardial imaging, although still investigational, is finding wide application. The principle of vasodilator thallium-201 myocar-dial imaging was first put forward by Strauss and Pitt,' who used dimethyladenosine in dogs with experimental coronary artery narrowing. They demonstrated that dimethyladenosine increased coronary blood flow and thallium-201 uptak...

We have studied the use of ultrapurified polymerized bovine haemoglobin (HBOC-201) in patients undergoing preoperative haemodilution before liver resection. After autologous blood donation of 1 litre, 12 patients (six males, six females, mean age 59 (35-69) yr) received Ringer's lactate solution 2 litre and, in a random design, 6% hydroxyethyl starch 70,000/0.5 (HES) 3 ml kg-1 or HBOC-201 0.4 g...

Background: Cartilaginous tumours may present diagnostic and prognostic dilemmas. Heterogeneity of appearance and histology sometimes confound our ability to make accurate diagnoses of the state of malignancy and grade. Conventional methods that combine history, plain radiographs, and histology may result in both under and over treatment. A method, which allows preoperative assessment of malign...

Creatine kinase-MB isoenzyme release (CK-MB-g-Eq) was correlated with left ventricular (LV) radionuclide gated blood pool wall motion estimates of percent abnormally contracting regions (%ACR), ejection fraction (EF) and quantitative thallium-201 (Tl-201) LV perfusion scintigraphy (Tl-201 perfusion index) during evolving myocardial infarction (MI). Of the 35 patients, 14 had no evidence of eith...