Restriction of energy intake induces a loss of body mass that is often regained when the restriction ends. We aimed to determine whether dietary energy density (independent of macronutrient composition) modulates postrestriction regain of body mass. Fifteen female mice consumed ad libitum a standard rodent diet (with 20% added cellulose). They were then subjected to a 20% energy restriction on ...

A bioassay of azobenzene for possible carcinogenicity was conducted by administering the test chemical in feed to F344 rats and B6C3F1 mice. Groups of 50 rats of each sex were administered azobenzene at one of two doses, either 200 or 400 ppm, for 105 or 106 weeks. Matched controls consisted of 20 untreated rats of each sex. All surviving rats were killed at the end of administration of the tes...

BACKGROUND The aim of the present study was to determine if long-term use of a cyclooxygenase-2 (COX-2) inhibitor affects fertility or ovulation in female mice. METHODS Twenty-four female mice, 25 days of age, were given a selective COX-2 inhibitor: 3 mg/kg celecoxib (n = 8), 5 mg/kg celecoxib (n = 8),or placebo (n = 8) in a random fashion. Eight female mice, 10-11 weeks old, given 3 mg/kg ce...

The 1995 to 1997 lifetime carcinogenicity studies of insulin glargine in rats and mice were reanalyzed and reassessed for their validity according to current guidelines. In 2-year studies, 50 animals per sex and per group were used. Survival rates between weeks 80 and 90 in female mice and rats were greater than 20 animals in all groups, fulfilling current Food and Drug Administration requireme...

The anti-inflammatory action of silver nanoparticles (NPs) has been reported in a murine model of asthma in a previous study. But more specific mechanisms of silver NPs in an attenuation of allergic airway inflammation have not yet been established. Vascular and mucous changes are believed to contribute largely in pathophysiology in asthma. Among various factors related to vascular changes, vas...

A bioassay for possible carcinogenicity of technical-grade dibromochloropropane (DBCP) was conducted using Osborne-Mendel rats and B6C3F1 mice. DBCP in corn oil was administered by gavage 5 days a week, at either of two dosages, to groups of 50 male and 50 female animals of each species. Initial dosage levels for the chronic bioassay were selected on the basis of a preliminary subchronic toxici...

In this paper I compare cost-benefit analysis (CBA) to multi-criteria analysis (MCA). I review the nature of the two approaches and consider the criticisms that have been made of CBA. I conclude that these criticisms largely lack merit, and that even to the extent to which they are meritorious, they provide no justification for relying on MCA. I conclude by expressing my concerns about the grow...

Objective: The study was conducted to evaluate the effects of lead acetate and protective role of garlic extract on the histomorphology of the ovarian follicles in an animal model. Study Design: Laboratory based randomized control trial Place and Duration of Study: Department of Anatomy, Army Medical College in collaboration with National Institute of Health from April—June 2013 Material and Me...