This paper reviews the pharmacological properties of Mediterranean-grown citrus species (Citrus L., Rutaceae), including citron (Citrus medica L.), lime (Citrus xauantiifolia [Christm.] Swingle), lemon (Citrus xlimon [L.] Osbeck), bitter orange (Citrus xaurantium L.) and pomelo (Citrus maxima [Burm.] Merr.), as referred to in ancient, medieval and 16th century sources. The virtues of the specie...