The recurrence rate in patients who undergo surgery for abdominal wall hernias (AWHs) is high. AWHs have been hypothesized to be a disease of the extracellular matrix, which supported by evidence showing high incidence with connective tissue disorders. This study aimed investigate most recent literature studies describing levels several matrix metalloproteinases (MMPs) blood and fascia, objecti...

Background: Leukemia is a malignant proliferative disorder of the hematopoietic cells. The important role of angiogenesis in leukemia has been reported by several studies. Matrix metalloproteinases (MMPs) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. Objective: The present study was conducted to evaluate the patterns of ...

background: leukemia is a malignant proliferative disorder of the hematopoietic cells. the important role of angiogenesis in leukemia has been reported by several studies. matrix metalloproteinases (mmps) are a large group of endopeptidases which degredate the extracellular matrix and play an important role in angiogenesis. objective: the present study was conducted to evaluate the patterns of ...

Background: Rosmarinic acid (RA) is a natural phenolic compound that acts as Fyn inhibitor by 53 homology modeling of the human structure. Therefore, apoptosis mechanism related to NF-κB signaling pathway induced RA in HepG2 was investigated. Methods: The cell growth, apoptosis, and proliferation regulated various concentrations were studied. proteins expression MMP-2, MMP-9, PI3K, AKT, NF-κB, ...

Purpose: Although osteosarcoma is the most common primary malignant bone tumor among adolescents and young adults, molecular mechanisms underlying development of cancer are not fully elucidated. Cyclophosphamide (CYC) an alkylating antineoplastic agent widely used in treatment regimens various cancers chronic inflammatory diseases. The aim this study to reveal effect CYC on Saos-2 cells at leve...