Quinoline based new Schiff bases were synthesized from 3-Actyl 4-Hydroxy Quinolin-2-(1H)-one and screened their antibacterial antifungal activity. The 4-hydroxy-3-(1-((4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one(L1),4-hydroxy-3-(1-((5-picolin-2-yl)imino)ethyl)quinolin-2(1H)-one(L2),4-hydroxy-3-(1-((6-picolin-2-yl)-imino)ethyl)quinolin-2(1H)-one(L3) 4-hydroxy-3-(1-((3-nitro-4-picolin-2-yl)imi...

Background Triple negative breast cancer (TNBC) is a heterogeneous subgroup (ER-, PR-, and HER2-) of invasive breast cancer, associated to poor prognosis, partially due to its resistance to available drugs. Therefore, it is imperative to discover new treatment options for the disease. In this context, we have synthesized and screened novel naphtoquinone-derived drugs (patent-protected), rationa...

In the title compound, C(14)H(17)N(2)O(4)P·CH(3)OH, the planes of the pyridinium-2-ylamino and 2-hydroxy-phenyl groups form a dihedral angle of 75.6 (1)°, with the pyridinium NH group and the 2-hydroxy-phenyl OH group pointing in opposite directions. Three intra-molecular hydrogen bonds are observed. Two phospho-nate and two methanol mol-ecules are connected by O-H⋯O hydrogen bonds as a centros...

The title compound, C(14)H(10)Br(2)N(2)O(3)·H(2)O, was synthesized by the reaction of 3,5-dibromo-2-hydroxy-benzaldehyde with an equimolar amount of 4-hydroxy-benzohydrazide in methanol. The structure comprises a Schiff base unit and a water mol-ecule of crystallization. The dihedral angle between the benzene rings in the Schiff base is 1.3 (3)°. In the crystal structure, mol-ecules are linked ...