A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air...

The front cover picture, designed by Tsuchimoto, illustrates the world of formation o-bis(3-indolyl)arenes that we had not anticipated. Before starting this research project, our purpose was to develop a unique-forming process 3-arylindoles reacting indoles with 7-oxabicyclo[2.2.1]hept-5-en-2-one in presence (Lewis) acid catalyst and H−Si. Contrary expectations, treatment two substrates CF3SO3H...

The use of quantitative structure–activity relationships, since its advent, has becomeincreasingly helpful in understanding many aspects of biochemical interactions in drug research.This approach was utilized to explain the relationship of structure with biological activity ofantibacterial. For the development of new fungicides against, the quantitative structural–activityrelationship (QSAR) an...

objective(s) in recent years concerns have been raised regarding the incidence of male reproductive disorders from exposure to endocrine disruptors. so, chronic effects of di(2-ethylhexyl)phthalate were studied on histological and stereological structure of testis in adult wistar rats. materials and methods thirty two adult wistar rats were randomly divided in four equal experiment groups; oil ...

There are currently no registered drugs that slow the progression of neurodegenerative diseases, in part because translation from animal models to the clinic has been hampered by poor distribution to the brain. The present studies examined a selected series of para-phenyl-substituted diindolylmethane (C-DIM) compounds that display anti-inflammatory and neuroprotective efficacy in vitro. We post...

The study synthesized a supramolecular complex of glycyrrhizic acid and β -indolyl-3-acetic in 4:1 ratio isolated from the root plant licorice (Glycyrrhiza glabra L.). resulting GA:IAA (4:1) was chemically identified based on comparison IR – Fure spectra starting agents.