Burkitt-type acute lymphoblastic leukemia (B-ALL) is thought as a variant of Burkitt lymphoma/leukemia and derived from mature B-cell lymphoblast.B-ALL was developed in a 10-year-old girl. Two characteristics were apparent in this case. First, the lymphoblastic cells were positive for CD10, CD19, CD20, and CD22, but negative for terminal deoxynucleotidyl transferase and surface immunoglobulins,...

Chromosome 1q? Levinson et al. (1) reported the results of a meta-analysis of families showing no major schizophrenia locus on chromosome 1q. These results, based on a multicenter study of affected sibling pairs (ASPs), are in striking contrast to findings of several recent papers reporting susceptibility loci on 1q in extended families. Significant linkage (LOD 6.5) at 1q21-22 was detected in ...

Received 16 March 2008; accepted 4 May 2008 Abstract: We classify the maximal irreducible periodic subgroups of PGL(q,F) , where F is a field of positive characteristic p transcendental over its prime subfield, q 6= p is prime, and F× has an element of order q . That is, we construct a list of irreducible subgroups G of GL(q,F) containing the centre F×1q of GL(q,F) , such that G/F×1q is a maxim...

Basal cell carcinomas, the most common human tumors, generally appear sporadically and in small numbers. Rarely, they may appear in great numbers and at an earlier age as a manifestation of the basal cell nevus syndrome, an autosomal dominant inherited disorder. Drawing on the retinoblastoma paradigm, we have begun a search for tumor suppressor genes important in the development of basal cell c...

De novo copy-number variants (CNVs) can cause neuropsychiatric disease, but the degree to which they occur somatically, and during development, is unknown. Single-cell whole-genome sequencing (WGS) in >200 single cells, including >160 neurons from three normal and two pathological human brains, sensitively identified germline trisomy of chromosome 18 but found most (≥ 95%) neurons in normal bra...

A de novo tandem duplication 1q32--q42 was observed in a 7-month-old mentally retarded and malformed male infant. Karyotype-phenotype correlation in other similar unbalanced trisomies has shown psychomotor retardation, micro- or retrognathia or both, and low set or malpositioned ears to be the most common features associated with this newly recognised syndrome. However, after reviewing patients...

We investigate the class of ±1 polynomials evaluated at q defined as: A(q) = { 0 + 1q + · · · + mq : i ∈ {−1, 1}} and usually called spectrum, and show that, if q is the root of the polynomial xn − xn−1 − · · · − xk+1 + xk + xk−1 + · · · + x + 1 between 1 and 2, and n > 2k + 3, then A(q) is discrete, which means that it does not have any accumulation points.

The belief that a morbid condition is attributable to their genes may lead parents to limit the size of the sibship in two ways. If the belief precedes the birth of an affected individual (A), the parents may decline to take the risk of producing another. We may then say that the criterion of termination is A = 1. If they have no such preconception, the birth of a second affected sib may lead t...

We characterize the space of multipliers between certain weighted Besov spaces of analytic functions. This extend and give a new proof of a result of Wojtaszczyk about multipliers between Bergman spaces. Introduction. P. Wojtaszczyk [W], using certain factorization theorems due to Maurey and Grothendieck, proved the following results: Let α > 0, 0 < p ≤ 2 ≤ q < ∞ and 1r = 1 p − 1q . (0.1) (Bq, ...

Immunoglobulin light chain (AL) amyloidosis is a rare plasma cell dyscrasia characterized by the deposition of abnormal amyloid fibrils in multiple organs, thus impairing their function. In the largest cohort studied up to now of 118 CD138-purified plasma cell samples from previously untreated immunoglobulin light chain amyloidosis patients, we assessed in parallel copy number alterations using...