OBJECTIVE(S) The role of the Apoptosis repressor with caspase recruitment domain (ARC) in apoptosis and in certain hypertrophic responses has been previously investigated, but its regulation of Endothelin-1 induced cardiac hypertrophy remains unknown. The present study discusses the inhibitory role of ARC against endothelin-induced hypertrophy. RESULTS In present study Endothelin treated card...

Abbreviations: GSTs: Glutathione S-Transferases; DM: Myotonic Dystrophy; PROMM: Proximal Myotonic Myopathy; ROS: Reactive Oxygen Species; Ile: Isoleucine; Val: Valine; EMG: Electromyographia; NCV: Nerve Conduction Velocity; OD: Optical Density; SNP: Single Nucleotide Polymorphisms; LWD: Learning and Writing Disability; SLD: Speech and Languages Disability; SCK: Serum Creatine Kinase; CK-MM: Cre...

introduction: cardiac preconditioning represents the most potent and consistently reproducible method of rescuing heart tissue from undergoing irreversible ischemic damage. the aim of the present study was to evaluate oxytocin (ot) induced cardioprotection and its signaling pathways on lactate dehydrogenase (ldh) and creatine kinase-mb isoenzyme (ck-mb) in the anesthetized rats. methods: eighty...

Background. Mortality from acute myocardial infarction with ST-segment elevation in cardiac hospitals ranges 4.5 to 7 %, and these data has not decreased recent years. The most common cause of death patients is cardiogenic shock, the likelihood which directly depends on infarct size. It quite clear that there an urgent need create drugs limit size prevent occurrence shock. aim. To evaluate role...

We reported previously that dietary isoflavones modulate arterial blood pressure in vivo and that the daidzein metabolite equol rapidly activates endothelial NO synthase (eNOS) via Akt and extracellular signal-regulated kinase 1/2-dependent signaling. In this study, we report the first evidence in human endothelial cells that acute stimulation of mitochondrial superoxide generation by equol (10...