Psoriasis is a chronic inflammatory skin disease characterized by T helper (Th) 17 axis maintained IL-17A and IL-17F produced Th17 cells (Lynde et al., 2014Lynde C.W. Poulin Y. Vender R. Bourcier M. Khalil S. Interleukin 17A: toward new understanding of psoriasis pathogenesis.J Am Acad Dermatol. 2014; 71: 141-150Abstract Full Text PDF PubMed Scopus (212) Google Scholar) keratinocyte (KC) stimul...

BCAS3 microtubule-associated cell migration factor (BCAS3) is a large, highly conserved cytoskeletal protein previously proposed to be critical in angiogenesis and implicated human embryogenesis tumorigenesis. Here, we established loss-of-function variants as causative for neurodevelopmental disorder. We report 15 individuals from eight unrelated families with germline bi-allelic BCAS3. All pro...

After chemotherapy, tumor cells with multidrug resistance (MDR) often emerge. MDR is attributable to the expression of membrane transport proteins that inhibit the cellular influx and increase the efflux of many chemotherapeutic drugs. One such protein is P-glycoprotein (P-gp), which functions as an ATP-dependent active transporter. Recently, an anti-P-gp monoclonal antibody (MAb) that inhibits...