BACKGROUND Hypertrophic cardiomyopathy is a genetically heterogeneous myocardial disease with >1000 causal variants identified. Nonunique variants account for disease in many families. We sought to characterize nonunique variants in Australian families and determine whether they arise from common ancestral mutations or recurrent mutation events. METHODS AND RESULTS Genetic test results of 467...

MicroRNAs (miRs) have been recognised as important regulators of malignant behaviour in different types of human cancer, including nasopharyngeal carcinoma (NPC). A previous study by our group revealed that miR-185-3p regulates the radioresistance of NPC cells. The present study aimed to investigate the effect of miR-185-3p on NPC invasion and metastasis. Human NPC CNE-2 and 5-8F cell lines wer...

BACKGROUND Replacement of the ascending aorta (Asc Ao) at the time of aortic valve replacement (AVR) is controversial because the risk of progressive dilatation following valve replacement is uncertain. Our aim was to determine the natural history of ascending aortic dilatation following AVR. METHODS AND RESULTS We studied 185 patients undergoing AVR at our institution between 1992 and 1999. ...

Abstract Background It is estimated that at least 12-15% of abdominal operations lead to incisional hernias, and Worldwide, evidence shows high rates recurrence after surgical repair ranging from 12.7% in the Danish hernia registry 23% Swedish registry. Method This a retrospective analysis practice single surgeon tertiary centre. An electronic database provided all surgeries done by surgeon. A ...

The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell lymphoma (MCL) cells, and is believed to be associated with the pathogenesis of this disease. XPO1-selective inhibitors of nuclear export (SINE) compounds have been shown to induce apoptosis in MCL cells. Given that p53 is a cargo protein of XPO1, we sought to determine the significance of p53 activation through XPO1 i...

1 Dr K Shilpa, MBBS,MD (DVL), Assistant Professor 2 Dr B Leelavathy, MBBS, MD(DVL), Professor and Head 3 Dr K Kavya, MD, Junior Resident 4 Dr DV Lakshmi, DVD, Junior Resident 5 Dr G Divya, MBBS,MD(DVL), Senior Resident Department of Dermatology, Venereology, Leprology, Bangalore Medical College and Research Institute, Bangalore. KR Market, Bengaluru-560002, Karnataka, India Corresponding author...

The main products of the 185 nm photolysis of neat liquid tetrahydropyran are pent-4en-l-ol (7) (0 = 0.40), 2-(5'-hydroxypentyl)tetrahydropyran (10) (0.21), valeraldehyde (6) (0.13), and pentan-l-ol (8) (0.08). These products are thought to be formed via the biradical '0(0112)40112, and/or through intramolecular (6, 7, 8) and intermolecular (10) photoreactions. In the case of 10, the probabilit...

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