The anticonvulsant effect of cannabinoids has been shown to be mediated through activation of the cannabinoid CB(1) receptor. This study was initiated to evaluate the effects of endogenously occurring cannabinoids (endocannabinoids) on seizure severity and threshold. The anticonvulsant effect of the endocannabinoid, arachidonylethanolamine (anandamide), was evaluated in the maximal electroshock...

PURPOSE To analyze the role and translational potential for hypermethylation of CpG islands and shores in the regulation of small RNAs within urothelial cell carcinoma (UCC). To examine microRNAs (miR) and mirtrons, a new class of RNA located within gene introns and processed in a Drosha-independent manner. EXPERIMENTAL DESIGN The methylation status of 865 small RNAs was evaluated in normal a...

We present evidence that at least two of the three 1811–1812 New Madrid, central United States, mainshocks and the 1886 Charleston, South Carolina, earthquake triggered earthquakes at regional distances. In addition to previously published evidence for triggered earthquakes in the northern Kentucky/southern Ohio region in 1812, we present evidence suggesting that triggered events might have occ...

Purpose: To analyze the role and translational potential for hypermethylation of CpG islands and shores in the regulation of small RNAs within urothelial cell carcinoma (UCC). To examinemicroRNAs (miR) and mirtrons, a new class of RNA located within gene introns and processed in a Drosha-independent manner. Experimental design: Themethylation status of 865 small RNAswas evaluated in normal andm...

Charles Dickens' ( 1812- 1870) works, were for a long time, a solid background for social, historical, psychological, literary and medical 19th century studies. In this article , some light is casted on Dickens, medicine and disabled people in his works, especially on paraplegics.