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Isozymes of glutathione reductase (GR) have been purified from red spruce (Picea rubens Sarg.) needles. Two isozymes could be separated by anion-exchange chromatography from both nonhardened or cold-hardened tissue. Based on chromatographic elution profiles, the isozymes were designated GR-1NH and GR-2NH in preparations from nonhardened needles, and GR-1H and GR-2H in preparations from hardened...
Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
The glucocorticoid receptor (GR) is a member of the nuclear receptor superfamily, which controls programs regulating cell proliferation, differentiation, and apoptosis. We have identified an unexpected role for GR in mitosis. We discovered that specifically modified GR species accumulate at the mitotic spindle during mitosis in a distribution that overlaps with Aurora kinases. We found that Aur...
We start with a warm-up: we explain Nakajima’s construction of the geometric sl2-action on ⊕ v Hmid(T ∗Gr(v, w)). 1.1. Warm-up: Nakajima’s geometric action. The lagrangian subvariety φ−1(0) ⊂ M(v) is easily seen to be the zero section Gr(v, w) ⊂ T ∗Gr(v, w). Indeed, consider the action of C× on M(v) induced from the C×-action on T ∗R by fiberwise dilations. Under the identification ofM(v) with ...
Regulation of hippocampal glucocorticoid receptor gene transcription and protein expression in vivo.
Glucocorticoid receptors (GRs) are glucocorticoid-activated transcription factors that modulate expression of a variety of neuronal genes. Appropriate control of GR expression is therefore critical for maintenance of cellular and organismic homeostasis. The present study assessed glucocorticoid regulation of the GR at the gene, mRNA, and protein level. Removal of circulating glucocorticoids (ad...
Glucocorticoids (GCs) bind to the cellular glucocorticoid receptors (GRs) to exert anti-inflammatory and immunosuppressive actions. We investigated the changes in the expressions of the two GR isoforms, GR-alpha and GR-beta, in nasal polyps treated with GC. Immunofluorescent staining revealed prominent expression of GR-alpha in the inflammatory cell infiltrate in the polyps obtained from patien...
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