Although microRNAs (miRNA) have been broadly studied in cancer, comparatively less is understood about their role in progression. Here we report that miR-153 has a dual role during progression of colorectal cancer by enhancing cellular invasiveness and platinum-based chemotherapy resistance. miRNA profiling revealed that miR-153 was highly expressed in a cellular model of advanced stage colorec...

centroid, 19, 25, 30 circular displacement, 102 code convolutional, 36, 58 Elias, 256 Gallager-vanVoorhis, 255 Golomb, 218, 254 Golomb–Rice, 188 Levenstein, 256 monotonic, 254 prefix-free, 239 terminated convolutional, 37 trellis, 38 unary, 254 zero-tail terminated convolutional, 37 codebook, 26, 27 adaptive, 154 adaptive gain, 155 stochastic, 156 stochastic gain, 156 codec ACELP, 158 code exci...

We have recently shown that upregulation of glutamate transporter 1 (GLT1) in the brain is associated in part with reduction in ethanol intake in alcohol-preferring (P) male rats. In this study, we investigated the effects of a synthetic compound, (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline (MS-153), known to activate GLT1 on ethanol consumption as well as GLT1 expression and certain signaling p...

PURPOSE Samarium-153 ethylene diamine tetramethylene phosphonate ((153)Sm-EDTMP), a bone-seeking radiopharmaceutical, provides therapeutic irradiation to osteoblastic bone metastases. Because the dose-limiting toxicity of (153)Sm-EDTMP is thrombocytopenia, a dose-escalation trial using peripheral-blood progenitor cells (PBPCs) or marrow support was conducted to treat metastatic bone cancer. P...

The aim of this study was to investigate co-expression of des-γ-carboxy prothrombin (DCP) and c-Met in hepatocellular carcinoma (HCC) and its significance in predicting tumor recurrence after surgical resection. Immunohistochemical techniques were used to examine DCP and c-Met expression in HCC samples collected from 153 patients. DCP and c-Met staining were observed in tumor areas in 63.4% (97...

Acute graft-versus-host disease (aGVHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Therefore, seeking reliable biomarkers and delineating the potential biological mechanism are important for optimizing treatment strategies and improving their curative effect. In this study, using a microRNA polymerase chain reaction (PCR)-based chip ass...

We present a growth model in which the work morale of R&D workers is endogenously determined by fair wage considerations and show that increases in endowments of researchers do not necessarily have positive growth effects. The results is in line with the empirical observations that the very large increases in the number of R&D workers during the last 30 years have not generated the growth rates...

PSA-TRICOM is a therapeutic vaccine in late stage clinical testing in metastatic castration-resistant prostate cancer (mCRPC). Samarium-153-ethylene diamine tetramethylene phosphonate (Sm-153-EDTMP; Quadramet®), a radiopharmaceutical, binds osteoblastic bone lesions and emits beta particles causing local tumor cell destruction. Preclinically, Sm-153-EDTMP alters tumor cell phenotype facilitatin...

multiple sclerosis (ms) is a complex disease which is correlated with increasing inflammatory factors, demyelination and axonal loss. in this auto-immune disease, neuroinflammation is mediated by different types of t cells with macrophage/microglial activation and b cells involvement that interact in a collaborative manner. focal inflammation is the main cause for the onset of relapses and coul...