Among the present classes of calcium channel blockers, dihydropyridine derivatives are widely used in the therapy of hypertension, angina pectoris and the other cardiovascular diseases. Since the prototype of dihydropyridine derivatives, nifedipine, does not have the optimum pharmacokinetic and pharmacodynamic characteristics, several attempts have been made to synthesize other drugs in this ...

activity and a wide spectrum against both Gram-positive and Gram-negative bacteria1~4). This high activity is due to good diffusion through the outer membranein Gram-negative organisms5), high affinities for penicillinbinding proteins (PBPs)6'7) and high stability and inhibitory activity against /Mactamases8). However, carbapenems were hydrolyzed by dehydropeptidase-I (DHP-I) from several anima...

Here we describe the efficient synthesis of alkyl 4-arylsubstituted-6-chloro-5-formyl-2-methyl-1,4-dihydropyridine-3-carboxylates and 4-arylsubstituted-4,7-dihydro-furo[3,4-b]pyridine-2,5(1H,3H)-diones via microwave-accelerated reaction of alkyl 4-arylsubstituted-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylates with the appropriate reagents. This eco-friendly approach to these valuable ...

A protein that imitates the sequence of a highly conserved segment predicted to line the pore of dihydropyridine-sensitive L-type calcium channels was designed and synthesized. Single-channel conductance properties were studied in planar lipid bilayers. The synthetic protein emulates the ionic conductance, ionic selectivity, and pharmacological properties of the authentic calcium channel, inclu...

Calcium channels are known to exist in muscle, neuronal and secretory cells. The 1,4-dihydropyridines are potent blockers of L-type Ca channels, and have been used as specific probes in the study of dihydropyridine-sensitive Ca channels. The receptor for the 1,4-dihydropyridines has been purified from skeletal muscle in order to characterize the biochemistry and molecular biology of the dihydro...

Axially enantioselective binuclear gold(I) catalysts fly as swallowtail butterflies around a mechanical hand providing chiral environment. The gold microchip on the symbolizes crucial role of catalysis in alkyne activation. Using gold-catalyzed condensation amine and diyne-ene, first example 1,2-dihydropyridine synthesis through formal [3+2+1] fashion is reported by Xin Hong, Xiaodong Shi et al...

In the title compound, C(21)H(27)NO(5), the dihydropyridine ring adopts a boat conformation. The ethoxy-phenyl ring is oriented approximately perpendicular to the planar part of the dihydropyridine ring, making a dihedral angle of 89.45 (6)°. An intra-molecular C-H⋯O hydrogen bond generates an S(6) ring motif. In the crystal structure, neighbouring mol-ecules are linked into chains along the a ...