Our understanding of brain metabolism and neuronal-astrocytic interactions are continuously changing and evolving as better tools become available for unraveling the metabolic specialization(s) and interactions of brain cells. Techniques including improved microscopy, cell isolation techniques, targeting of specific tagged/inducible genes and fluorescent proteins to specific organelles such as ...

A new anthraquinone derivative, 1,8-dihydroxy-2-[(z)-4-methylpenta-1,3-dien-1-yl] anthraquinone (1), together with known anthraquinone compounds were defined to be, 2-acetyl-3,8-dihydroxy-6-methoxyanthraquinone (2) , emodin (3), glucofrangulin A (4) and phenanthrene derivative named dendrochrysanene (5), lactone compounds named [-sorigenin (6) and geshoidin (7)], xanthone compound termed pruni...

The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to possess potent tyrosinase inhibitory activity.The structures of the synthesized compounds were ascertained by their spectroscopic data (FTIR, 1H...

The new a-pyrone derivative II was isolated in crystalline form from extracts of dormant seeds of Rosa canina. It inhibits germination of seeds of Amaranthus caudatus completely, but reversibly, at conc. > 2.5 x 10~5 m . Its chemical structure was elucidated by mass spectrometry, 'Hand 13CNMR spectroscopy to be 3-methyl-l-oxa-bicyclo (4,1,0) hept-5-en-2-one-4,6-dicarboxylic acid di­ methylester...

Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmacological actions. However, the clinical efficacies of these antimalarial drugs have been compromising due ...

Abstract Electronic interactions in donor-π-linker-acceptor systems with barbituric acid as an electron acceptor and possible donor were investigated to screen promising candidates a push–pull character based on experimental quantum chemical studies. The tautomeric properties of 5-benzylidenebarbituric derivatives studied NMR spectra, spectrophotometric determination the pKa values, calculation...

يتضمن البحث تحضيرحامض الاثيلين ثنائي الامين رباعي حامض الخليك اللامائي [ 1] من خلال تفاعلمع (ethylene diamine tetraacetic acid) EDTA مادة الخليكحامض وبوجود البيريدين تحت ظروف التصعيد.في الخطوة الثانية التحضير العضوي تم مفاعلة المركب مع الكحول الحاوي على حلقة غير متجانسةليتكون استرالخلات الثنائي 2] في تركيبه مجموعة الاستر tetrahydrofurfuryl alcoholوالحلقة المتجانسة بشكل ثنائي.تم تنقية المركبات ا...

Quinoline based new Schiff bases were synthesized from 3-Actyl 4-Hydroxy Quinolin-2-(1H)-one and screened their antibacterial antifungal activity. The 4-hydroxy-3-(1-((4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one(L1),4-hydroxy-3-(1-((5-picolin-2-yl)imino)ethyl)quinolin-2(1H)-one(L2),4-hydroxy-3-(1-((6-picolin-2-yl)-imino)ethyl)quinolin-2(1H)-one(L3) 4-hydroxy-3-(1-((3-nitro-4-picolin-2-yl)imi...