Up to date, miR-137 has been demonstrated as a tumor suppressor in many kinds of human malignancies. In the present study, we conducted transfection, western blot and RT-PCR to explore the role of miR-137 in the development of human glioblastoma (GBM). Here, we found that miR-137 expression was obviously down-regulated in GBM tissues and cells rather than matched non-tumor tissues and NHA cells...

The aim of this paper is to revisit the question local–global principles for embeddings étale algebras with involution into central simple over global fields characteristic not 2. A necessary and sufficient condition given in Bayer-Fluckiger et al. (J Eur Math Soc 20:137–163, 2018). In present paper, we give a simpler description obstruction group. It also shown that if algebra product pairwise...

We sought to analyze the current situation of personnel training and scientific research regarding pharmacy intravenous admixture services (PIVAS), provide evidence-based medical knowledge inform for PIVAS in mainland China. A cross-sectional survey was used examine status training, capabilities, needs, output based from perspective leaders The period March April 2019. total 137 hospitals China...

The rapid growth in the number of users of mobile communications means that many operators must find new ways of increasing the capacity of their networks. Their options include allocating more frequency, introducing frequency-hopping techniques, and adding microcells and adaptive antenna systems. The introduction of new frequency bands at 1800 and 1900 MHz is an example of allocating frequency...

Th is research note describes an interconnection between touristic potential of localities impacted by the First and the Second World War, by focusing on a case study of cemeteries in the North-East of Slovakia. Th e case study proposes to create a Slovak part of the ‘dark tourism thematic trail’ through cemeteries from the First World War that could join the existing Polish part of the trail a...

Carboxyl-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that represses expression of various tumor suppressor genes. In the present study, we identified miR-137 as a potential regulator of CtBP1 expression in melanoma cells. Expression of miR-137 in melanoma cell lines was found to inversely correlate with CtBP1 levels. Target Scan predicted a putative site for miR-137 wit...

the purpose of this study was to assess the process of extension program development in iranian agricultural extension system (iaes). the research instrument was a structural questionnaire with close-ended questions which its validity and reliability was confirmed by using expert panel and cranach’s alpha test, respectively. the target population of this research included all extension managers...

________________________________________ Introduction __ ___________________________________ Area covered.__________________________________ Aeromagnetic survey.___________________________ Gravity survey.________________________________ Acknowledgments--.. __1________________________ Geology __ __ ____________ _ Rock units_____________________________________ Carboniferous and older rocks._____...

Small angle x-ray scattering was used to follow changes in the conformation and interactions of nucleosome core particles (NCP) as a function of the monovalent salt concentration C(s). The maximal extension (D(max)) of the NCP (145 +/- 3-bp DNA) increases from 137 +/- 5 A to 165 +/- 5 A when C(s) rises from 10 to 50 mM and remains constant with further increases of C(s) up to 200 mM. In view of...

The molecular mechanisms underlying colorectal cancer (CRC) development remain elusive. In this study, we examined the miRNA and mRNA expressions in the adenoma-carcinoma sequence (ACS), a critical neoplastic progression in CRC development. We found that miR-137 was down-regulated in all adenoma and carcinoma tissues. Low miR-137 levels were correlated negatively with tumor progression and meta...