MicroRNAs play an important role in the regulation of cancer migration, invasion and metastasis. Patients with triple-negative breast cancer (TNBC) have a high incidence of early relapse and metastasis; however, the molecular basis for metastasis and recurrence in these individuals remains largely unknown. Herein, we demonstrate that miR-136 is an anti-invasive microRNA in TNBC and suppresses m...

The killer toxin from Pichia membranifaciens CYC 1106, a yeast isolated from fermenting olive brines, binds primarily to the (136)-b-D-glucan of the cell wall of a sensitive yeast (Candida boidinii IGC 3430). The (136)-b-D-glucan was purified from cell walls of C. boidinii by alkali and hot-acetic acid extraction, a procedure which solubilizes glucans. The major fraction of receptor activity re...

Aims and method Two police liaison and section 136 schemes were developed alongside police services at different sites within the same NHS trust. In one, a mental health nurse worked with frontline police attending incidents related to mental health. The other involved nurses providing advice from the police control room. Section 136 detentions were measured over two 6-month periods (6 months a...

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We have evaluated over a period of 18 months the use of 16S ribosomal DNA (rDNA) sequence analysis as a means of identifying aerobic gram-positive rods in the clinical laboratory. Two collections of strains were studied: (i) 37 clinical strains of gram-positive rods well identified by phenotypic tests, and (ii) 136 clinical isolates difficult to identify by standard microbiological investigatio...

Pyrrolobenzodiazepine dimers are an emerging class of warhead in the field of antibody-drug conjugates (ADCs). Tesirine (SG3249) was designed to combine potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. One of the reactive imines was capped with a cathepsin B-cleavable valine-alanine linker. A robust sy...

One hundred fourteen high-lean growth gilts (72.5 kg BW) were used to determine the apparent digestible lysine requirement for maximum growth performance and carcass protein deposition rate from 72.5 to 136 kg BW. The experiment was a randomized complete block design with initial BW used to establish blocks. Six dietary treatments were included, ranging from .44 to .94% (.10% increments) appare...

a Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, 842W. Taylor St., Chicago, IL 60607-7022, USA b School of Mechanical Engineering, Korea University, Seoul, 136-713, Korea c School of Civil, Environmental & Architectural Engineering, Korea University, Seoul 136-713, Korea d Department of Environmental Science & Ecological Engineering, Korea University, Se...