BACKGROUND Human epididymis protein 4 (HE4), a precursor of human epididymis protein, has been proposed as a tumor marker for ovarian cancer. We evaluated HE4 in comparison with cancer antigen 125 (CA 125) in healthy individuals and in patients with benign and malignant diseases. METHODS CA 125 and HE4 serum concentrations were determined in 101 healthy individuals, 535 patients with benign p...

OBJECTIVES The objective of this study is to investigate the effects of Salviae Miltiorrhizae Radix hot aqueous extract on nitric oxide (NO) and prostaglandin E2 (PGE2 ) production and on 1,1-diphenyl-2-picryl hydrazyl (DPPH) free-radical scavenging in macrophages. METHODS Salviae Miltiorrhizae Radix(300 g) was heated at 100℃ with distilled water (2 L) for 4 hours. The extract was filtered an...

AIMS We investigated whether radiation-induced nontargeted effects are involved in the cytotoxic effects of anticell surface monoclonal antibodies labeled with Auger electron emitters, such as iodine 125 (monoclonal antibodies labeled with (125)I [(125)I-mAbs]). RESULTS We showed that the cytotoxicity of (125)I-mAbs targeting the cell membrane of p53(+/+) HCT116 colon cancer cells is mainly d...

abstract salinity is one of the major abiotic challenges influencing plant productivity worldwide. to examine the response of two alfalfa cultivars (bami and hamedani) to six levels of water salinity (0, 25, 50, 75, 100, 125 mm l-1 nacl), a glasshouse experiment was conducted at the college of agriculture, shiraz university, shiraz, iran in 2008. the results showed that in bami (which appeared...

The medicinal plants have been used since ancient times and are still utilized by the majority of the population. Hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. The aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in Iran as an herbal remedy.  The cytotoxicity was tested in vitro using Allium cepa L. r...

The production of pro-inflammatory and anti-inflammatory cytokines, as well adipocyte differentiation fat accumulation in the 3T3-L1 mouse embryo fibroblast cell line human monocytic THP-1 were measured to determine antiadipogenic effects ethanolic extracts verjuice (unripe grape juice (Vitis vinifera L.)), Salvia officinalis L., Alchemilla vulgaris L. On both lines, three had much greater cyto...

Transport of thyroid hormone across the cell membrane is required for thyroid hormone action and metabolism. We have investigated the possible transport of iodothyronines by the human system L amino acid transporter, a protein consisting of the human 4F2 heavy chain and the human LAT1 light chain. Xenopus oocytes were injected with the cRNAs coding for human 4F2 heavy chain and/or human LAT1 li...