نتایج جستجو برای: 11q23 translocation

تعداد نتایج: 47169  

Journal: :Neuro-oncology 2013
Terri Rice Shichun Zheng Paul A Decker Kyle M Walsh Paige Bracci Yuanyuan Xiao Lucie S McCoy Ivan Smirnov Joseph S Patoka Helen M Hansen George Hsuang Joe L Wiemels Tarik Tihan Alexander R Pico Michael D Prados Susan M Chang Mitchel S Berger Alissa Caron Stephanie Fink Thomas Kollmeyer Amanda Rynearson Jesse Voss Matthew L Kosel Brooke L Fridley Daniel H Lachance Jeanette E Eckel-Passow Hugues Sicotte Brian Patrick O'Neill Caterina Giannini John K Wiencke Robert B Jenkins Margaret R Wrensch

INTRODUCTION Recent discoveries of inherited glioma risk loci and acquired IDH mutations are providing new insights into glioma etiology. IDH mutations are common in lower grade gliomas and secondary glioblastomas and uncommon in primary glioblastomas. Because the inherited variant in 11q23 has been associated with risk of lower grade glioma and not with glioblastomas, we hypothesized that this...

Journal: :Blood 1997
K Mrózek K Heinonen D Lawrence A J Carroll P R Koduru K W Rao M P Strout R E Hutchison J O Moore R J Mayer C A Schiffer C D Bloomfield

Following reports of childhood acute myeloid leukemia (AML) showing that patients with t(9; 11)(p22; q23) have a better prognosis than those with translocations between 11q23 and other chromosomes, we compared response to therapy and survival of 24 adult de novo AML patients with t(9; 11) with those of 23 patients with other 11q23 translocations [t(11q23)]. Apart from a higher proportion of Fre...

Journal: :Blood 1999
M Dördelmann A Reiter A Borkhardt W D Ludwig N Götz S Viehmann H Gadner H Riehm M Schrappe

To define prognostic factors in infant acute lymphoblastic leukemia (ALL), the outcome of 106 infants (age </=12 months) during 3 consecutive multicenter trials of the Berlin-Frankfurt-Münster group (ALL-BFM 83, 86, and 90) was retrospectively analyzed according to presenting features and early in vivo response to prednisone. The prednisone response was defined as the cytoreduction (number of b...

Journal: :Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti 2010
Z Mikulásová D Ilencíková T Slamka D Durovcíková

One of the most common chromosomal breakpoint regions in acute myeloid leukaemia is the chromosome band 11q23. The analysis of this region led to the discovery of the extremely promiscuous MLL gene, in which more than 60 MLL translocation partner genes have been described. Among the most frequent are t(9;11)(p21-22;q23)/MLL-AF9, t(10; 11)(p13; q23)/MLL-AF10, t(11;19)(q23;p13)/MLL-ELL, ENL and t...

Journal: :Blood 2005
Jolanta Libura Diana J Slater Carolyn A Felix Christine Richardson

Rearrangements involving the MLL gene on chromosome band 11q23 are a hallmark of therapy-related acute myeloid leukemias following treatment with topoisomerase II poisons including etoposide. Therapy-related and de novo genomic translocation breakpoints cluster within a well-characterized 8.3-kb fragment of MLL. Repair of etoposide-stabilized DNA topoisomerase II covalent complexes may initiate...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1986
C A Griffin C McKeon M A Israel A Gegonne J Ghysdael D Stehelin E C Douglass A E Green B S Emanuel

Recurring, site-specific chromosomal rearrangements are associated with several human syndromes and malignant disorders. Such nonrandom translocations involving chromosome 22 in band q11 are numerous and found to be associated with a diversity of neoplasms as well as constitutional disorders. Chromosome 11 in bands q23-q24 is similarly involved in several types of tumors as well as in a recurri...

1997
Janet D. Rowley Shalini Reshmi Olatoyosi Sobulo Tarannum Musvee John Anastasi Susana Raimondi Nancy R. Schneider Julio C. Barredo Eduardo S. Cantu Brigitte Schlegelberger Frederick Behm Norman A. Doggett Julian Borrow Nancy Zeleznik-Le

The involvement of 11q23-balanced translocations in acute some variability in the breakpoint because it was on the leukemia after treatment with drugs that inhibit the function der(16) in three patients, on the der(11) in another, and split of DNA topoisomerase II (topo II) is being recognized with in four others. We assume that the critical fusion gene is increasing frequency. We and others ha...

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