PURPOSE Anti-PD1 and PD-L1 antibodies are associated with immune-related adverse effects (irAEs). This analysis aims to assess the discrepancies between frequencies of irAEs observed in phase 1 trials with those seen in late-phase trials and to evolve the field of drug development. METHODS PubMed search was conducted for articles published until December of 2016. Trials needed to have at leas...

A parameterised Boolean equation system (PBES) is a set of equations that defines sets satisfying the equations as the least and/or greatest fixed-points. Thus this system is regarded as a declarative program defining predicates, where a program execution returns whether a given ground atomic formula holds or not. The program execution corresponds to the membership problem of PBESs, which is ho...

The symbolic manipulation program Schoonschip is being made freely available for a number of computers with Motorola 680x0 cpu’s. It can run on machines with relatively modest memory and disk resources, and is designed to run as fast as possible given the host constraints. Memory and disk utilization can be adapted to tune performance. Recently added capabilities include a system for efficient ...

Intense ultrasonic beams suffer progressive waveform distortion due to the nonlinearity of air, causing numerous harmonics be generated in beam. Since these harmonic pressures can theoretically predicted with sufficient accuracy by Khokhlov-Zabolotskaya-Kuznetsov model, it is possible obtain pressure sensitivity a microphone at high frequencies. To generate intense waves, planar aperture source...

OBJECTIVE The audibility thresholds for the sound frequency of 137 upward- and downward-sloping audiograms showing sensorineural hearing loss were selected and analyzed in conjunction with speech recognition thresholds obtained from individuals seen at a public otolaryngology clinic to determine which frequencies in slope audiograms best represent speech recognition thresholds. METHOD The lin...

Improving Nurse Retention in the British National Health Service: The Impact of Job Satisfaction on Intentions to Quit In recent years the National Health Service (NHS) in Britain has experienced an acute shortage of qualified nurses. This has placed issues of recruitment and retention in the profession high on the political agenda. In this paper we investigate the determinants of job satisfact...

We present new wide-field observations of Centaurus A (Cen A) and the surrounding region at 118 MHz with the Murchison Widefield Array (MWA) 32-tile prototype, with which we investigate the spectral-index distribution of Cen A’s giant radio lobes. We compare our images to 1.4 GHz maps of Cen A and compute spectral indices using temperature-temperature plots and spectral tomography. We find that...

We investigated single nucleotide polymorphisms (SNP) at 87 sites of the phosphodiesterase 4D (PDE4D) gene in Mongol and Han patients with ischemic stroke in Inner Mongolia. SNPs in 226 patients with ischemic stroke (case group, 110 Mongol patients, 116 Han patients) and 220 patients without neurological disease (control group, 102 Mongol patients, 118 Han patients) were detected by polymerase ...