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Pin1 is a peptidyl prolyl cis-trans isomerase that only binds to and isomerizes phosphorylated serine/threonine-proline motifs, inducing conformational changes that alter target protein function and phosphorylation. We have shown previously that deficiency of another peptidyl prolyl isomerase, FK506 binding protein 12/12.6, alters endothelial NO synthase phosphorylation and causes endothelial d...

Four new sporochartines B–E were isolated from the marine fungus Hypoxylon monticulosum CLL-205, isolated from a sponge belonging to the Sphaerocladina order and collected in Tahiti coast. Sporochartine A (1), the first representative of this family was previously isolated from the same fungus. The structures of sporochartines B–E were elucidated using 1D and 2D NMR, HRMS and IR data. Their con...

The anticancer activities of ginsenosides are widely reported. The structure-activity relationship of ginsenosides against cancer is not well elucidated because of the unavailability of these compounds. In this work, we developed a transformation method to rapidly produce rare dehydroxylated ginsenosides by acid treatment. The optimized temperature, time course, and concentration of formic acid...

Corrigendum to “Nk6, a novel Drosophila homeobox gene regulated by vnd” [Mech. Dev. 116 (2002) 105–116] Jay Uhler, James Garbern, Li Yang, John Kamholz, Dervla M. Mellerick* Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA Department of Neurology, Wayne State University School of Medicine, Detroit, MI 48201, USA Center for Molecular Medicine and Genetics, Wayne State Un...