RATIONALE Acute doses of buprenorphine can precipitate withdrawal in opioid dependent persons. The likelihood of this withdrawal increases as a function of the level of physical dependence. OBJECTIVES To test the acute effects of sublingual buprenorphine/naloxone tablets in volunteers with a higher level of physical dependence. The goal was to identify a dose that would precipitate withdrawal...

background: the rosemary extract (re) possesses various antioxidant, cytoprotective and cognition-improving bioactivities. in this study, we postulated which doses of re have a more effect on the hippocampus of middle-aged rats.   methods : in this experimental study, thirty-two middle-aged male wistar rats were fed by different doses (50,100 and 200 mg/kg/day) of re (containing 40% carnosic ac...

Background: This analysis reports the impact of eptinezumab on work productivity and daily activities in patients with migraine prior preventive treatment failures. Methods: The DELIVER study (NCT04418765) randomized adults documented evidence 2-4 failures to receive 100mg, 300mg, or placebo (IV every 12 weeks). At baseline 4 weeks, completed migraine-specific 6-question Work Productivity Activ...

616 Nefrologia 2011;31(5):607-26 at a dosage of 180mg/12 hours. This treatment is maintained to date. Vesical transurethral resection in 2009 due to vesical neoplasm and atrial fibrillation. His usual treatment was: acetylsalicylic acid 100mg, bisoprolol 2.5mg/24 hours, omeprazole 20mg/24 hours, calcium carbonate 2.5g/24 hours, dacortin 5mg/24 hours and MMF 180mg/24 hours. He was administered E...

Propolis is a natural resinous substance (bee glue) collected by honey bees. The aim of the study was to perform phytochemical analysis of different extracts of propolis viz. ethanolic extract, methanolic extract and water extract. The antibacterial activity was studied by using Well diffusion method and Macro Broth dilution method against Salmonella typhimurium at different concentration like ...

Purpose of the study Atazanavir is a good but expensive regimen in resource limited settings (RLS). A previous HIV-NAT study showed that a low dose of ATV/r 200/100mg once daily (QD) provided adequate atazanavir plasma concentrations in HIV-infected Thai adults. Reducing the dose would make atazanavir more accessible to those patients in need in RLS. We aimed to evaluate long term efficacy of l...

Gray and Loh (1) have shown previously that dietary ƒ¿-tocopheryl acetate (ƒ¿ TAc) brings about increases in phospholipids, total and free cholesterol in the plasma of healthy human subjects. It seemed probable that the dietary ƒ¿TAc affected the liver cell itself, the blood being merely a transport medium. This hypothesis was investigated, using rat liver homogenates from animals main tained f...

The present study was conducted to evaluate the hepatoprotective activity of methanolic extract of aerial parts of Plumbago zeylanica in CCl4-induced hepatotoxicity in wistar rats. Silymarin (100mg/kg, p.o.) was given as reference drug. The extract of aerial parts of Plumbago zeylanica have shown very significant hepatoprotection against CCl4-induced hepatotoxicity in wistar rats by reducing se...

Anti histaminic activity of cissus quadrangularis stem powder was carried out determining the histamine activity and histamine content in carrageenin induced rat paw swelling model and formalin induced peritonitis respectively. The crude powder at the dose of 100mg/1QQ00 gm exerted reduction to the maximum of 44% in the early hisamine phase swelling. Further it significantly reduced the histami...

Methods A 37 year-old Para1 was diagnosed of left ventricle non-compaction (LVNC) at 32 years old, after a previous successful pregnancy without complications. Prior to the current pregnancy, the patient presented with a left ventricle ejection fraction (LVEF) of 44% and NYHA class II. Her medical treatment included 100mg acetyl salicylic acid (ASA) daily and Carvedilol. Significant family hist...