Objective: Our recent studies have demonstrated voltagegated KCNQ channels (KCNQ1-KCNQ5) as key regulators of detrusor smooth muscle (DSM) function. Despite emerging developments, the physiological role of individual KCNQ channel subtypes remains less clear. Here, we utilized the novel compound ML-213, a potent activator of KCNQ2, KCNQ4, and KCNQ5 channels, to elucidate their physiological role...

OBJECTIVES Investigators and clinicians almost always rely on Diagnostic and Statistical Manual of Mental Disorder, 4th edition's (DSM-IV) somatoform disorders (and its derivative diagnoses) to characterize and identify patients with medically unexplained symptoms (MUS). Our objective was to evaluate this use by determining the prevalence of DSM-IV somatoform and nonsomatoform disorders in pati...

background and aims: students experience some degrees of mental disorders during their life. therefore, the present study was conducted to determine the prevalence and risk factors of mental disorders among the secondary school students in ilam, iran. methods: this is a cross sectional study, carried out among the secondary school students in ilam, iran. we assessed 841 students including 446 m...

Protein kinase C (PKC) and large conductance Ca(2+)-activated potassium channels (BK) are downregulated in the detrusor smooth muscle (DSM) in partial bladder outlet obstruction (PBOO). DSM from these bladders display increased spontaneous activity. This study examines the involvement of PKC in the regulation of spontaneous and evoked DSM contractions and whether pharmacologic inhibition of PKC...

The organization and management of the intense computation involved in the solution of large, sparse and non-symmetric systems of equations, arising from the discretization of Elliptic Boundary Value Problems (BVPs) by the Hermite Collocation method, on a Distributed-Shared Memory (DSM) multiprocessor environment is the problem considered herein. As the size of the problem directly suggests the...

Intraarterial administration of 40-microns degradable starch microspheres (DSM) in a drug solution can temporarily retard flow of the drug-blood column through the arteriolar-capillary bed and lead to increased local drug deposition. Premonitory to Phase II-III efficacy studies applying this concept to regional therapy, it was necessary to determine the DSM dose to use. Patients with hepatic ca...

characteristics of the sample and methodology are published elsewhere [7]. Our database comprised 1,005 individuals above the age of 65 who were interviewed from a predefined catchment population in Chennai, India. This corresponded to a response rate of 72% [3]. The calculations for sample size [7] , the detailed report of the survey, and the characteristics of the catchment population are des...

The present study explored the prevalence of anxiety disorders among adults seeking speech therapy for stuttering. Employing a matched case-control design, participants included 92 adults seeking treatment for stuttering, and 920 age- and gender-matched controls from the Australian National Survey of Mental Health and Well-being. A conditional logistic regression model was used to estimate odds...

Substance use disorders have undergone major changes in both the international (ICD-10) and American (DSM-IV) nosological systems, thus necessitating a study of cross-system agreement between ICD-10 and DSM-IV substance dependence, especially from a developing country setting. Further, endorsement rates for various substance dependence criteria in the two systems need to be studied from a simil...

Solar cadasters are excellent tools for determining the most suitable rooftops and areas PV deployment in urban environments. There several open models that available to compute solar potential cities. The Energy on Building Envelopes (SEBE) is a powerful model incorporated geographic information system (QGIS). main input these digital surface (DSM). accuracy of DSM can contribute significantly...