Abstract: Background: From the wide range of previous literature studies indicated that thiazolidinedione’s reacts with substituted benzaldehydes undergoes knoevenagel condensation gives respective arylidene derivatives. In our attempt all titled compounds were designed and developed by replacement furan- 2-aldehyde, so furan moiety was introduced in molecule. Materials Methods: 5-[(furan-2-yl)...

In the present work, novel 7-aryl-10, 11-dihydro-7H-chromeno [4, 3-b]quinoline-6, 8(9H, 12H)-dione derivatives were synthesized by oxidation of 7-aryl-8, 9, 10, 12-tetrahydro-7H-chromeno[4, 3-b]quinoline-6, 8-diones in the presence of silica sulfuric acid/NaNO2 with yields of 64-74%. Cytotoxic activity of synthesized compounds was assessed on three different human cancer cell lines (K562, LS180...

3,3,6,6-Tetramethyl-9-phenyl-3,4,6,7,9,10-hexahydroacridine-1,8-(2H,5H)-dione derivatives are synthesized by nano titanium dioxide as an efficient and reusable heterogeneous nano catalyst in a one pot multi component reaction. Easy preparation and separation of catalyst, simply workup procedure, clean reaction and reusability of the catalyst up to 7 times without appreciable loss of its catalyt...

To continue our systematic SAR studies a series of N-phenylamino derivatives of 2-azaspiro[4.4]nonane-, 2-azaspiro[4.5]decane-, 6-methyl-2-azaspiro[4.5]decane-1,3-dione and 3-cyclohexylpyrrolidine-2,5-dione were synthesized and tested for their anticonvulsant activity in the maximum electroshock seizure (MES) and subcutaneous metrazole seizure threshold (sc. Met) tests. Among those molecules th...

Abstract: Background: Diabetes mellitus, a lifestyle related global health crisis has rapidly engulfed the entire world. In past, various thiazolidinedione derivatives have been successfully developed for management of diabetes. Materials and Methods: Herein, we report synthesis, characterization (1H-NMR, 13C-NMR mass spectroscopy methods) novel aryl sulfonyloxy-5-arylidene thiazolidine-2,4-dio...

The effect of the three cyclohexane-1,3-dione derivatives cycloxydim, sethoxydim and clethodim on the incorpora­ tion of l4C-labelled acetate, malonate, acetyl-CoA or malonyl-CoA into fatty acids was studied in an enzyme preparation isolated from barley chloroplasts (H ordeum vulgare L. var. “A lexis”). The herbicides cycloxydim, clethodim and sethoxydim block the de novo fatty acid biosynthesi...

The previous studies in a series of 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives revealed their analgesic properties. We extended the study with these compounds in aim to assess their impact on inflammatory process. For this purpose we used: the zymosan-induced peritonitis and the carrageenan-induced edema model. Furthermore, the antioxidant activity of the investigated compounds by ...