The binding affinity of a curvature-sensing protein domain (N-BAR) is measured as a function of applied osmotic stress while the membrane curvature is nearly constant. Varying the osmotic stress allows us to control membrane tension, which provides a probe of the mechanism of binding. We study the N-BAR domain of the Drosophila amphiphysin and monitor its binding on 50 nm-radius vesicles compos...

We present the design, fabrication and characterization of a new all-optical frequency modulated pressure sensor. Using the tangential strain in a circular membrane, a waveguide with an integrated nanoscale Bragg grating is strained longitudinally proportional to the applied pressure causing a shift in the Bragg wavelength. The simple and robust design combined with the small chip area of 1 × 1...

Pure and aqueous methanol were used for radiation induced incorporation of CO at elevated pressure (up to 15 bar). The initial yields (G,) of the main products in pure methanol under 15 bar CO and 1 bar N 20 were found to be: G, (formaldehyde) = 3.80 and G;(glycolic aldehyde) = 2.0. For aqueous (10“ 2 mol • dm -3 ) methanol under 15 bar CO (dose: 0.557 kGy, pH — 2): the yields were G (formaldeh...

To investigate the use of linear diode laser bars to optically stretch cells and measure their mechanical properties, we present numerical simulations using the immersed boundary method (IBM) coupled with classic ray optics. Cells are considered as three-dimensional (3D) spherical elastic capsules immersed in a fluid subjected to both optical and hydrodynamic forces in a periodic domain. We sim...

Many cells in cat and monkey visual cortex (area V1 and area 17) respond to gratings and bar patterns of different orientation between center and surround [18]. It has been shown that these cells respond on average 3.3 times stronger to a crossing pattern than to a single bar [16]. In this paper a computational model for a group of neurons that respond solely to crossing patterns is proposed, a...

Previously, we reported a micro magnetic stir-bar mixer driven by an external rotating magnetic field and its rapid mixing performance in polydimethyl-siloxane (PDMS) channels. The PDMS piece with embedded fluid channels were manually aligned to a glass substrate and assembled. In this paper, we report the fabrication and testing results of a micro magnetic stir-bar monolithically integrated in...

Critical insights on galaxy evolution stem from the study of bars. With the advent of high redshiftHST surveys that trace bars in the rest-frame optical band out to z ∼ 1, it becomes increasingly important to provide a reference baseline for bars at z ∼ 0 in the optical band. We present results on bars at z ∼ 0 in the optical and near-infrared bands, based on 180 spirals in the OSUBSGS survey. ...

The experimental goal of the MuCap experiment at the Paul Scherrer Institute (PSI) is a high-precision measurement of the singlet capture rate of the nuclear muon capture on the free proton in the reaction m þp-nþnm. The measuring principle is a lifetime measurement whereas the experimental approach is based on a specially developed Time Projection Chamber (TPC) operating with ultra-pure and de...

High resolution OVRO CO 1-0 observations of the inner kpc of the M51-companion NGC 5195 reveal the presence of a kpc-sized bar, or possibly an inclined disk with a two armed spiral, at the center of the optical bar. The molecular mass of the feature is 2.7 × 10 M⊙, half of which is within a radius of 250 pc. The resulting gas surface density of 10 M⊙ pc −2 is typical for starbursts. However, th...