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Increased cellular production of vascular endothelial growth factor (VEGF) is responsible for the development and progression of multiple cancers and other neovascular conditions, and therapies targeting post-translational VEGF products are used in the treatment of these diseases. Development of methods to control and modify the transcription of the VEGF gene is an alternative approach that may...
Our object is to formulate and analyze a physically plausible and mathematically sound model to better understand the phenomenon of clustering in colloids. The term depletion force refers to the force (in the Newtonian sense) which is associated with the clustering. Our model is stochastic but derived from a deterministic setup in a Newtonian setting. A mathematical transition from the determin...
With few exceptions, all living organisms encode the same 20 canonical amino acids; however, it remains an open question whether organisms with additional amino acids beyond the common 20 might have an evolutionary advantage. Here, we begin to test that notion by making a large library of mutant enzymes in which 10 structurally distinct noncanonical amino acids were substituted at single sites ...
2. The biology of the oocyte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 2.1. Oogenesis and development . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 2.2. Bioelectrical properties of the oocyte . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 215 2.3. The oocyte at work...
Photoreductive titration of the resonance Raman spectra of cytochrome oxidase in whole mitochondria.
A photoreductive titration of the resonance Raman (RR) spectra of cytochrome c oxidase in whole mitochondria was recorded by exploiting the preferential enhancement of the Raman signals of reduced cytochrome oxidase excited at 441.6 nm. When the sample was cooled to about--10 degrees C, it was possible to slow down the photoreductive effect of the laser and to record RR spectra at various state...
For some years in this laboratory the principles and methods of quantitative histochemistry introduced by Linderstr#{216}m-Lang and loiter (7, 10) have been used for studies on the chemical pathology of the nervous system. A particular effort has been made to describe the biochemical architecture of rat and human cerebral cortex, primarily because of its intrinsic neurological importance and th...
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