INTRODUCTION There are numerous studies addressing associations of polymorphisms in DNA repair genes and cancer risks because accurate and efficient DNA repair is crucial to genomic integrity and fidelity. ERCC1 is important in DNA nucleotide excision repair. MATERIAL AND METHODS We genotyped constitutive variants of ERCC1 in approximately 300 adults with breast adenocarcinoma and 126 control...

Site segregation of coexisting ectoparasite species may result either from a direct interaction such as resource competition between them or from a host-mediated interaction. Here we present an individual-based model for the coevolution of 1 host and 2 parasite species to study this latter hypothesis. Parasite species are generalists at the start of the simulation and develop site specificities...

BACKGROUND Atlases of brain anatomical ROIs are widely used for functional MRI data analysis. Recently, it was proposed that an atlas of ROIs derived from a functional brain parcellation could be advantageous, in particular for understanding how different regions share information. However, functional atlases so far proposed do not account for a crucial aspect of cerebral organization, namely h...

conclusions the at1r a1166c polymorphism appeared not to be associated with the presence of acs in the population studied. background there are very limited data for iranian populations on the predisposing genetic factors for acute coronary syndrome (acs). results there was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (p > 0....

Material and Methods Materials. Neurobasal medium, B27, SUPERSCRIPT II RNase H reverse transcriptase, RNAaseOUT, and Taq polymerase were from Invitrogen (Paisley, Scotland); papain was from Worthington Biochemical Corp. (Lakewood, NJ); NaAsO2, cysteine, soybean trypsin inhibitor (STI), propidium iodide (PI), Hoechst 33342, and the bicinchoninic acid protein assay kit were from Sigma (Poole, Dor...

Stor y s p ace, a hy p er text wr i ti ng env i r onm ent, has been w i dely us ed for wri ti ng, read i ng, and res ear ch for near ly f i fteen year s. Th e ap p ear ance of a new im p lem entati on p r ov i d es a sui table occas i on to rev i ew th e des i gn of Stor y s p ace, both in its hi s tor i cal context and in th e context of contem p or ar y res ear ch . Of par ti cu lar inter es ...

Geriatric medicine has an encyclopaedic sweep, reflecting the complexity of both the ageing process and of our patient group. Keeping up with, and making sense of, the relevant scientific literature is challenging, especially as ageing has increased in prominence as a focus of research across many branches of the sciences and the humanities. This review of research published in 2012 in generali...

As the Royal College of Nursing Congress drew to a close in Harrogate members were in no doubt their national pay campaign had gathered momentum. It was no longer just about a 3 per cent pay rise for every nurse in the country, but about the future of the NHS itself.