PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively eva...

objective: 8-methoxypsoralen (8-mop) is a photoactive compound widely used in the treatment of proliferate disorders. the present study investigates the effects of 8-mop on ovary function and pituitary-gonad axis in mice. materials and methods: in this experimental analytical study, 45 female balb/c mice were divided into three groups (n=15), control, sham (olive oil injection) and experimental...

8-Methoxy psoralen (8-MOP) exerts a short-term (24 h) mitogenic action, and a long-term (48-72 h) anti-proliferative and melanogenic action on two human melanoma cell lines, SK-Mel 28 and C32TG. An increase of intracellular calcium concentration was observed by spectrofluorometry immediately after the addition of 0.1 mM 8-MOP to both cell lines, previously incubated with calcium probe fluo-3 AM...

7-Methylguanine was found in hydrolysates of liver and pancreas DNA from Syrian golden hamsters given a single dose of N-[1-14C]nitrosobis(2-oxopropyl)amine (BOP). This led us to examine the carcinogenicity of a potential methylating metabolite of BOP, N-nitrosomethyl(2-oxopropyl)amine (MOP). MOP was found to be a potent pancreatic carcinogen by either single or weekly s.c. injections. A single...

In design and fabricate drive shafts with high value of fundamental natural frequency that represented high value of critical speed; using composite materials instead of typical metallic materials could provide longer length shafts with lighter weight. In this paper, multi-objective optimization (MOP) of a composite drive shaft is performed considering three conflicting objectives: fundamental ...

The bispecific monoclonal antibody (Bi-MAb) HRS-3/AP-1 was developed by somatic hybridization of the 2 mouse hybridoma cell lines HRS-3 and AP-1, which produce monoclonal antibodies with reactivity against the Hodgkin's- and Reed-Sternberg cell-associated CD30 antigen and alkaline phosphatase, respectively. After an active incubation with alkaline phosphatase, respectively. After an active incu...

Agronomic market development information provided by: Dr. Adrian Johnston Northern Great Plains Region Director Potash & Phosphate Institute (PPI)/ Potash & Phosphate Institute of Canada (PPIC) 12-425 Pinehouse Drive Saskatoon, Saskatchewan, Canada S7K 5K2 Phone: (306) 956-0619 E-mail: [email protected] THE ATMOSPHERIC CONCENTRATIONS of nitrous oxide (N 2 O), carbon dioxide (CO 2 ), and me...