The human immunodeficiency virus type 1 (HIV-1) vpu gene encodes a small integral membrane phosphoprotein with two established functions: degradation of the viral coreceptor CD4 in the endoplasmic reticulum (ER) and augmentation of virus particle release from the plasma membrane of HIV-1-infected cells. We show here that Vpu is also largely responsible for the previously observed decrease in th...

With no effective treatments available for most pancreatic cancer patients, pancreatic cancer continues to be one of the most difficult malignancies to treat. Oncolytic virus mediated-gene therapy has exhibited ubiquitous antitumor potential. In this study, we constructed a novel oncolytic vaccinia virus harboring the inhibitor of growth family member 4 gene (VV-ING4) to investigate its therape...

IFN-gamma-induced nitric oxide (NO) in the murine macrophage-derived cell line RAW 264.7 was previously shown to inhibit replication of the poxviruses ectromelia and vaccinia (VV) and HSV-1. In the current study we demonstrate that murine macrophages activated as a consequence of VV infection express inducible nitric oxide synthase. These activated macrophages were resistant to infection with V...

T-cell based vaccines have been considered as attractive candidates for prevention of hepatitis C virus (HCV) infections. In this study we compared the magnitude and phenotypic characteristics of CD8+ T-cells induced by three commonly used viral vectors, Adenovirus-5 (Ad5), Vaccinia virus (VV) and Modified Vaccinia Ankara (MVA) expressing the HCV NS3/4A protein. C57/BL6 mice were primed with DN...

AIMS Optimizing cardiac resynchronization therapy (CRT) devices has become more complex since modification of both atrioventricular (AV) and interventricular (VV) stimulation intervals has become possible. The current paper presents data from the routine use of impedance cardiography (IC)-based cardiac output (CO) measurements to guide the optimization of AV- and VV-interval timing of CRT devic...

Synthetic Aperture Radar (SAR) backscatter observations are sensitive to hydrologic conditions and vegetation characteristics of land cover. This study conducted a high spatial-resolution investigation (30-m) on the response dual-polarization C-band (5.6 cm wavelength) SAR coefficients (?°) temporal changes surface water depth (dw) spatial variations in south Florida Everglades wetlands. We inv...

Crop supply and management is a global issue, particularly in the context of climate change rising urbanization. Accurate mapping monitoring specific crop types are crucial for studies. In this study, we proposed: (1) methodology to map two main winter crops (winter wheat barley) northern region Finistère with high-resolution Sentinel-2 data. Different classification approaches (the hierarchica...

Abstract Marine pollution is one of issues that widely discussed such as marine debris, chemical contamination, and oil spill. It has many impacts on the environment. Remote sensing helps detect presence an spill via satellite platform. One commonly used Synthetic-Aperture Radar (SAR) imagery, which can see spills even in cloudy conditions. However, black white appearance radar sometimes makes ...