Leishmaniasis is the protozoan disease second in importance for human health, superseded only by malaria; however, the options for chemotherapeutic treatment are increasingly limited due to drug resistance and toxicity. Under this perspective, a quest for new chemical compounds is urgently needed. An N-substituted 2-aminoalkan-1-ol scaffold has been shown to be a versatile scaffold for antipara...

This study combines theory and experiment to determine the kinetically relevant steps and site requirements for deoxygenation of alkanols and alkanals. These reactants deoxygenate predominantly via decarbonylation (C-C cleavage) instead of C-O hydrogenolysis on Ir, Pt, and Ru, leading to strong inhibition effects by chemisorbed CO (CO*). C-C cleavage occurs via unsaturated species formed in seq...

Alkane-1-ols (abbreviation CnOH, n is the number of carbons in alkyl chain) are known as general anesthetics that do not obey the Meyer-Overton rule [1]. Their anesthetic potency increases up to C11OH and then decreases, compounds with n 13 are nonanesthetic, although the molar partition coefficient Kp between the lipid bilayers and aqueous phase increases exponentially in the whole region [2]....

All-atom molecular dynamics simulations are conducted to understand the structural and dynamical behavior of self-assembled monolayer of n-alkanols on a mica surface. In particular, we report the effect of increasing carbon chain length (C1− C10) on the self-assembly, surface diffusion, and preferential tilting of n-alkanol monolayer, for monolayer surface coverage ranging from 6 × 10−5 to 3.54...

Bacterial glycerol ether lipids (alkylglycerols) have received increasing attention during the last decades, notably due to their potential role in cell resistance or adaptation to adverse environmental conditions. Major uncertainties remain, however, regarding the origin, biosynthesis, and modes of formation of these uncommon bacterial lipids. We report here the preponderance of monoalkyl- and...

The noncanonical alcohol dehydrogenase AlkJ is encoded on the alkane-metabolizing alk operon of the mesophilic bacterium Pseudomonas putida GPo1. To gain insight into the enzymology of AlkJ, we have produced the recombinant protein in Escherichia coli and purified it to homogeneity using His6 tag affinity and size exclusion chromatography (SEC). Despite synthesis in the cytoplasm, AlkJ was asso...