04 and

نتایج جستجو برای: 04 and

تعداد نتایج: 16835511 فیلتر نتایج به سال:

S5B-04 SESSION 5B

Journal: :Plastic and Reconstructive Surgery - Global Open 2019

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Theoretical overview QM '04

Journal: :Journal of Physics G: Nuclear and Particle Physics 2004

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S16-04 SESSION 16

Journal: :Plastic and Reconstructive Surgery - Global Open 2019

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Alleles of HLA-DRB1*04 Associated with Pulmonary Tuberculosis in Amazon Brazilian Population

2016

Dhêmerson Souza de Lima Mauricio Morishi Ogusku Maisa Porto dos Santos Cláudia Maria de Melo Silva Vanessa Alves de Almeida Irineide Assumpção Antunes Antonio Luiz Boechat Rajendranath Ramasawmy Aya Sadahiro Carmen Infante-Duarte

Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1*04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazil...

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A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

2013

Stephen W. Scally Jan Petersen Soi Cheng Law Nadine L. Dudek Hendrik J. Nel Khai Lee Loh Lakshmi C. Wijeyewickrema Sidonia B.G. Eckle Jurgen van Heemst Robert N. Pike James McCluskey Rene E. Toes Nicole L. La Gruta Anthony W. Purcell Hugh H. Reid Ranjeny Thomas Jamie Rossjohn

Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 p...

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