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Franco Gherlinzoni, M.D., (1999–02) Michael Simon, M.D., (1999–02) Scott Nelson, M.D., (1999–02) Martine van Glabbeke, M.D., (1999–02) Ephraim Casper, M.D., (2000–03) Andrew Huvos, M.D., (2000–03) Martin Robinson, M.D., (2000–03) Junya Toguchida, M.D., (2000–03) Kristy Weber, M.D., (2001–04) Jean Yves Blay, M.D., (2001–04) Thomas DeLaney, M.D., (2001–04) Pancras Hogendoorn, M.D., (2001–04) H.J....
Immunogenetic host factors are associated with susceptibility or protection to tuberculosis (TB). Strong associations of HLA class II genes with TB are reported. We analyzed the HLA-DRB1*04 alleles to identify subtypes associated with pulmonary TB and their interaction with risk factors such as alcohol, smoking, and gender in 316 pulmonary TB patients and 306 healthy individuals from the Brazil...
Rheumatoid arthritis (RA) is strongly associated with the human leukocyte antigen (HLA)-DRB1 locus that possesses the shared susceptibility epitope (SE) and the citrullination of self-antigens. We show how citrullinated aggrecan and vimentin epitopes bind to HLA-DRB1*04:01/04. Citrulline was accommodated within the electropositive P4 pocket of HLA-DRB1*04:01/04, whereas the electronegative P4 p...
Cellular proteins are extensively degraded during leaf senescence, and this correlates with an up-regulation of protease gene expression, particularly cysteine proteases. The objectives of this work were (i) to detect cysteine proteases associated with senescence of wheat leaves under different conditions and (ii) to find out their subcellular location. Activity labelling of cysteine proteases ...
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