Polymorphism is a key feature of amyloid fibril structures but it remains challenging to explain these variations for a particular sample. Here, we report electron cryomicroscopy-based reconstructions from different fibril morphologies formed by a peptide fragment from an amyloidogenic immunoglobulin light chain. The observed fibril morphologies vary in the number and cross-sectional arrangemen...

Natural killer (NK) cell number and cytotoxicity are decreased in the blood of patients with a wide range auto-immune conditions. However, role NK cells dermatomyositis (DM) has not been explored. To quantify activity, we utilized signature score, summing standardized z-scores previously validated NK-specific gene set: Nkp46, CD160, KLRC3, CD244, KLRF1, KLRC1, GNLY, PRF1, XCL2, IL18RAP. Upregul...

A large class of dynamic systems can be decomposed into or approximated by cascaded subsystems. Applications include multi-agent systems, distributed process control, and hierarchical large-scale systems. Nonlinear dynamic systems can be represented as Takagi-Sugeno (TS) fuzzy models, with linear or affine consequents. For cascaded TS systems, it has been proven that the stability of the subsys...

Introduction Familial Mediterranean Fever (FMF) is considered a rare disease in Japan. Our institution began screening for MEFV gene mutations in patients with periodic fever in 2005. Among the 18 patients screened, we have identified 11 (56.5%) FMF patients with heterozygous M694I/E148Q mutations. Among the other 7 patients, no pathogenic mutations were detected by the direct sequencing of all...

This study examines how the accuracy of Qibla direction mosque is determined using one modern tools, namely Taracker Qibla, combined with qualitative descriptive methods through field research (Field Research), object matching several mosques in Tamalanrea District, Makassar City. The approach this uses a sociological synthesis approach. Researchers conducted deductive and inductive analyses co...