Bárbara Frias,1,2 João Santos,1 Marlene Morgado,3 Mónica Mendes Sousa,3 Susannah M.Y. Gray,6 Karen D. McCloskey,6 Shelley Allen,4 Francisco Cruz,2,5 and Célia Duarte Cruz1,2 1Department of Experimental Biology, Faculty of Medicine of Porto, University of Porto, 4200-319 Porto, Portugal, 2Translational NeuroUrology and 3Nerve Regeneration Group, IBMC–Instituto de Biologia Molecular e Celular, Un...

The closed irreducible 3-manifolds with finite fundamental group and containing an embedded Klein bottle can be identified with certain Seifert fibre spaces. We calculate the isotopy classes of homeomorphisms of such 3-manifolds. Also we prove that a free involution acting on a manifold of this type, gives as quotient either a lens space or a manifold in this class. As a corollary it follows th...

The MHC class I-related chain (MIC) A and MICB ligands for the activating receptor NKG2D can be shed from tumor cells, and the presence of these soluble molecules in sera is related with compromised immune response and progression of disease. Recently, thiol disulphide isomerases and members of the ADAM (a disintegrin and metalloproteinase) gene family were identified as key enzymes in mediatin...

Heteroresistance to antimicrobial agents may affect susceptibility test results and therapeutic success. In this study, we investigated heteroresistance to cephalosporins and penicillins in Acinetobacter baumannii, a major pathogen causing nosocomial infections. Two A. baumannii isolates exhibited heteroresistance to ampicillin-sulbactam, ticarcillin-clavulanic acid, cefepime, and cefpirome, sh...

This biographical sketch of Eugene F. Sanger, AM, MD, corresponds to the historic text, The Classic: Report of the Committee on Suits for Malpractice, available at DOI 10.1007/s11999-008-0639-z.

The Bacillus anthracis strain STI is a Soviet vaccine strain that lacks the pXO2 plasmid. Previous data indicate that this isolate forms a new branch within the B. anthracis sub-group originally identified as A. Br.008/009.