MACIEJ GARSTKA, IZABELA ADAMCZYK, MAŁGORZATA ROSIAK, JAN HENK VENEMA, BORYS KIERDASZUK, ANNA DROŻAK*, PHILIP R. VAN HASSELT, AGNIESZKA MOSTOWSKA and KATARZYNA GIECZEWSKA Department of Metabolic Regulation, Department of Plant and Cell Anatomy, *present address: Department of Plant Physiology, Faculty of Biology, Warsaw University, Miecznikowa 1, PL-02-096 Warsaw, Poland, Laboratory of Plant Phy...

D-004, a lipid extract from royal palm (Roystonea regia) fruits, has shown to inhibit prostate 5-α-reductase in vitro, and to prevent prostate hyperplasia (PH) induced with T, not with DHT, in rodents, but its potential estrogenic or antiestrogenic effects had not been studied yet. This study investigated whether D-004 produces estrogenic or antiestrogenic effects, as assessed in the uterotroph...

A new inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), HL-004 [N-(2, 6-diisopropylphenyl)tetradecylthioacetamide], suppressed the synthesis of cholesterol [14C]oleate at 10(-9) approximately 10(-7) M in a concentration-dependent manner in both THP-1 cell-derived macrophages and foam cells prepared from aortic intima of rabbits fed a high cholesterol diet. Incorporation of [3H]cholester...

Different properties of quasars may be observed and analysed through the many ranges electromagnetic spectrum. Pioneering studies showed that an "H-R diagram" for was needed to organize these data, more than two dimensions were necessary: a four dimensional Eigenvector (4DE1) parameter space proposed. The 4DE1 makes use independent observational obtained from optical UV emission lines, as well ...

Introduction With the increasing potential for targeted therapies in autoinflammatory diseases, there is the need for validated and standardized assessment tools which can be used to evaluate the level of disease activity and response to therapy.An international collaboration, initiated by Assistance Publique-Hôpitaux de Paris (APHP) in association with the Paediatric Rheumatology International...

Immunogenicity, manufacturing feasibility, and safety of a novel, autologous dendritic cell (DC)-based immunotherapy (AGS-004) was evaluated in ten human immunodeficiency virus type 1 (HIV-1)-infected adults successfully treated with antiretroviral therapy (ART). Personalized AGS-004 was produced from autologous monocyte-derived DCs electroporated with RNA encoding CD40L and HIV antigens (Gag, ...