Asfaha, Samuel, Cameron J. Bell, John L. Wallace, and Wallace K. MacNaughton. Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G703–G710, 1999.—Colonic epithelial secretion is an important host defense mechanism. We examined whether a bout of colitis would produce long-lasting changes i...

Kleine, Teri J., Gerald J. Gleich, and Simon A. Lewis. Eosinophil peroxidase increases membrane permeability in mammalian urinary bladder epithelium. Am. J. Physiol. 276 (Cell Physiol. 45): C638–C647, 1999.—Eosinophil peroxidase (EPO), a cationic protein found in eosinophils, has been reported to be cytotoxic independent of its peroxidase activity. This study investigated with electrophysiologi...

MARK O. BEVENSEE,1 ESTHER BASHI,1 WOLF-RÜDIGER SCHLUE,2 GREGORY BOYARSKY,3 AND WALTER F. BORON1 1Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520; 2Institut für Neurobiologie, Heinrich-Heine-Universität Düsseldorf, 40225 Düsseldorf, Germany; and 3Department of Physiology and Biophysics, University of Texas Medical Branch, Galvesto...

Das, Kumuda C., Xiao-Ling Guo, and Carl W. White. Induction of thioredoxin and thioredoxin reductase gene expression in lungs of newborn primates by oxygen. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L530–L539, 1999.— Thioredoxin (TRX) is a potent protein disulfide oxidoreductase important in antioxidant defense and regulation of cell growth and signal transduction processes, among them...

Cui, Jian, Satoshi Iwase, Tadaaki Mano, and Hiroki Kitazawa. Responses of sympathetic outflow to skin during caloric stimulation in humans. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R738–R744, 1999.—We previously showed that caloric vestibular stimulation elicits increases in sympathetic outflow to muscle (MSNA) in humans. The present study was conducted to determine the e...

Hayward, Linda F., and Robert B. Felder. Electrophysiological properties of rat lateral parabrachial neurons in vitro. Am. J. Physiol. 276 (Regulatory Integrative Comp. Physiol. 45): R696–R706, 1999.—Anatomical studies have demonstrated that the lateral parabrachial nucleus (LPBN) is composed of at least seven separate subnuclei distinguished by cell morphology, spatial clustering, and afferent...

Escherichia coli K-12 strains are normally tolerant to n-hexane and susceptible to cyclohexane. Constitutive expression of marA of the multiple antibiotic resistance (mar) locus or of the soxS or robA gene product produced tolerance to cyclohexane. Inactivation of the mar locus or the robA locus, but not the soxRS locus, increased organic solvent susceptibility in the wild type and Mar mutants ...

Mutant, but not wild-type p53 binds with high affinity to a variety of MAR-DNA elements (MARs), suggesting that MAR-binding of mutant p53 relates to the dominant-oncogenic activities proposed for mutant p53. MARs recognized by mutant p53 share AT richness and contain variations of an AATATATTT "DNA-unwinding motif," which enhances the structural dynamics of chromatin and promotes regional DNA b...

We investigated the effects of different directions of insertion of matrix attachment region (MAR) sequences on transgenic expression in stably transformed Chinese hamster ovary (CHO) cells. The MAR sequences were inserted in forward or reverse directions into the expression vectors, and transfected into CHO cells. The expression of the chloramphenicol acetyltransferase (CAT) reporter gene and ...

KARINA I. MAZZITELLO, CONSTANCIO M. ARIZMENDI∗, ALVARO L. SALAS BRITO† and HILARY G. E. HENTSCHEL‡ CONICET-Facultad de Ingenieŕıa, Universidad Nacional de Mar del Plata, Juan B. Justo 4302, B7608FDQ Mar del Plata, Argentina ∗Facultad de Ingenieŕıa, Universidad Nacional de Mar del Plata, Juan B. Justo 4302, B7608FDQ Mar del Plata, Argentina †Univ Autonoma Metropolitana Azcapotzalco, Lab Sistemas...