BACKGROUND We recently identified polymorphisms in Kaposi sarcoma-associated herpesvirus (KSHV)-encoded microRNA (miRNA) sequences from clinical subjects. Here, we examine whether any of these may contribute to KS risk in a European AIDS-KS case-control study. METHODS KSHV load in peripheral blood was determined by real-time quantitative polymerase chain reaction. Samples that had detectable ...

Kaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described: classical KS, endemic KS, iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been d...

BACKGROUND The diagnosis of gastrointestinal (GI) involvement in Kaposi's sarcoma (KS) is important to make because the need for treatment depends on the extent of the disease. Moreover, severe GI lesions can cause serious complications. Endoscopy with biopsy is an extremely useful method to diagnose GI-KS. However, determining the indications for endoscopy is difficult because KS can occur wit...

Sir, Kaposi’s sarcoma (KS) is a multifocal neoplastic process occurring predominantly in the dermal vasculature (1, 2). Bluish-red macules, plaques and tumours characterize the neoplasm, which most commonly affects the feet (1 – 3). The recognized clinical variants of KS include classic KS, endemic African KS, KS in iatrogenically immunocompromised patients and HIVassociated KS (1, 4). The disc...

OBJECTIVE To investigate the predictive factors for the development of Kaposi sarcoma-related immune reconstitution inflammatory syndrome (KS-IRIS) and long-term prognosis in patients starting combined antiretroviral therapy (cART). METHODS We studied a retrospective-cohort of consecutive antiretroviral-naïve patients with KS initiating cART from January 2005 to December 2011 and followed thr...

An n-by-n bipartite graph is H-saturated if the addition of any missing edge between its two parts creates a new copy of H. In 1964, Erdős, Hajnal and Moon made a conjecture on the minimum number of edges in a Ks,s-saturated bipartite graph. This conjecture was proved independently by Wessel and Bollobás in a more general, but ordered, setting: they showed that the minimum number of edges in a ...