RNA interference (RNAi) has just made it through the pipeline to clinical trials. However, in order for RNAi to serve as an ideal personalized therapeutics and be clinically approved-safe, specific, and potent strategies must be devised for efficient delivery of RNAi payloads to specific cell types, which despite the immense potential, remains a challenge. Through evaluating the recent reported...

By merging bottom-up and top-down strategies we tailor graphene's electronic properties within nanometer accuracy, which opens up the possibility to design optical and plasmonic circuitries at will. In a first step, graphene electronic properties are macroscopically modified exploiting the periodic potential generated by the self assembly of metal cluster superlattices on a graphene/Ir(111) sur...

The dimension of biomolecules is of few nanometers, so the biomolecular devices ought to be of that range so a better understanding about the performance of the electronic biomolecular devices can be obtained at nanoscale. Development of optical biomolecular device is a new move towards revolution of nano-bioelectronics. Optical biosensor is one of such nano-biomolecular devices that has a pote...

Rapid developments in nano-technology are likely to confer significant benefits on mankind. But, as with perhaps all new technologies, these benefits are likely to be accompanied by risks, perhaps by new risks. Nano-toxicology is developing in parallel with nano-technology and seeks to define the hazards and risks associated with nano-materials: only when risks have been identified they can be ...

ABSTRACT We developed a novel measurement method of dielectric constant of liquids in 10-10 nm space (extended-nano space). Using our streaming potential system [1], dielectric constant was measured by regarding an extended-nano channel as an electric circuit. We revealed that the dielectric constant of water in extended-nano space was dramatically decreased (approximately 1/4 in 580 nm channel...

The minimum size of a closed nano-space in which cells can survive was determined using 4-nl nanowells. One or two cells could divide in the nanowell. Our results suggest that the cell division activity in the nano-space is determined by the conflict between intercellular effects and consumption of substrates.

Generally, a fracture is considered as an uncontrollable thus useless phenomenon due to its highly random nature. The aim of this study is to investigate highly ordered cracks such as oscillatory cracks and to manipulate via elaborate control of mechanical properties of the cracking medium including thickness, geometry, and elastic mismatch. Specific thin film with micro-sized notches was fabri...

Unlike drugs and medical devices, for which long standing and continuously improving quality assurance/quality control infrastructures exist, many nano-based products lack well-defined standards that are useful to manufacturers and regulators. Inherent variabilities in nanoparticle sizes and shapes, their large surface-to-volume ratios, and their mesoscale interactions with subcellular structur...

Sensors that change color have the advantages of versatility, ease of use, high sensitivity, and low cost. The recent development of optically based chemical sensing platforms has increasingly employed substrates manufactured with advanced processing or fabrication techniques to provide precise control over shape and morphology of the sensor micro- and nano-structure. New sensors have resulted ...

The phase of graphene plasmon upon edge-reflection plays a crucial role on determining the spectral properties of graphene structures. In this article, by using the full-wave simulation, we demonstrate that the mid-infrared graphene plasmons are nearly totally reflected at the boundary together with a phase jump of approximately 0.27π, regardless of the environments surrounding it. Appling this...