نتایج جستجو برای: ژن stk11
تعداد نتایج: 16599 فیلتر نتایج به سال:
UNLABELLED The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung adenocarcinoma are poorly characterized. We performed an integrative analysis of genomic, transcriptomic, and proteomic data from early-stage and chemorefractory lung adenocarcinoma and identified three robust subsets of KRAS-mutant lung adenocarcinoma dominated, respectively, by co-occurring genetic events ...
Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder characterized by the development of hamartomatous polyposis in the gastrointestinal tract and melanin-pigmented macules on the skin mucosa. The responsible gene is a tumor suppressor, STK11/LKB1, on chromosome 19p13.3. PJS complicates with benign and malignant tumors in various organs. In gynecology, there has been a particular focu...
Introduction: Lung cancer is the second most common type both in males and females leading cause of death worldwide. Inside lung cancer, Non-Small-Cell Cancer (NSCLC) represents around 85% cases, where KRAS mutated oncogene (∼25%) confers poor prognosis a high risk tumor recurrence. Subsets mutant NSCLC have been described based on presence concurrent mutations suppressor genes (TSGs), being TP...
Colon polyps represent precursor lesions of colon cancers and their malignant potential varies according to histological subtype. A rare subtype of colon polyps is the Peutz-Jeghers (PJ) polyp. PJ polyps mostly occur in the context of Peutz-Jeghers syndrome, which is characterized by the development of multiple polyps in the intestinal tract and hyperpigmentation of oral mucosa and lips. Peutz-...
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